{"id":2896,"date":"2023-07-18T20:05:56","date_gmt":"2023-07-18T14:35:56","guid":{"rendered":"https:\/\/eliteayurveda.com\/blog\/?p=2896"},"modified":"2025-01-17T13:43:20","modified_gmt":"2025-01-17T08:13:20","slug":"the-relationship-between-hidradenitis-suppurativa-and-genetics","status":"publish","type":"post","link":"https:\/\/eliteayurveda.com\/blog\/the-relationship-between-hidradenitis-suppurativa-and-genetics\/","title":{"rendered":"The relationship between Hidradenitis Suppurativa and Genetics"},"content":{"rendered":"\n<p><strong>The Relationship Between Hidradenitis Suppurativa and Genetics: An Ayurvedic Perspective<\/strong><\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>Table of Contents<\/h2><nav><ul><li><a href=\"#understanding-hs-and-genetics\">Understanding HS and Genetics<\/a><ul><li><a href=\"#what-does-modern-science-say\">What Does Modern Science Say?<\/a><\/li><li><a href=\"#ayurvedic-perspective-on-genetics\">Ayurvedic Perspective on Genetics<\/a><\/li><\/ul><\/li><li><a href=\"#genetics-vs-environment-the-dual-impact\">Genetics vs. Environment: The Dual Impact<\/a><\/li><li><a href=\"#common-challenges-for-hs-patients-with-genetic-predisposition\">Common Challenges for HS Patients with Genetic Predisposition<\/a><\/li><li><a href=\"#ayurvedic-approach-to-genetic-predisposition-in-hs\">Ayurvedic Approach to Genetic Predisposition in HS<\/a><ul><li><a href=\"#key-ayurvedic-strategies\">Key Ayurvedic Strategies:<\/a><\/li><\/ul><\/li><li><a href=\"#ayurvedic-viewpoint-on-generational-healing\">Ayurvedic Viewpoint on Generational Healing<\/a><\/li><li><a href=\"#comparison-modern-genetics-vs-ayurvedic-approach\">Comparison: Modern Genetics vs. Ayurvedic Approach<\/a><\/li><li><a href=\"#why-choose-elite-ayurveda-for-hs\">Why Choose EliteAyurveda for HS?<\/a><\/li><li><a href=\"#real-stories-of-transformation\">Real Stories of Transformation<\/a><\/li><li><a href=\"#from-the-doctors-desk\">From the Doctor\u2019s Desk<\/a><\/li><li><a href=\"#your-path-to-holistic-healing-starts-here\">Your Path to Holistic Healing Starts Here<\/a><\/li><li><a href=\"#references\">References<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<p>Hidradenitis Suppurativa (HS), a chronic inflammatory skin condition, is not merely a disease of the skin but a systemic disorder with deeper roots. One of the most debated aspects of HS is its genetic predisposition. While Western medicine highlights genetic markers and familial clustering, Ayurveda delves into the role of inherited <em>Prakriti<\/em> (constitution) and doshic imbalances passed down through generations (Gupta &amp; Singh, 2017).<\/p>\n\n\n\n<p>At <strong>EliteAyurveda<\/strong>, we combine modern insights into genetics with ancient Ayurvedic wisdom, offering holistic solutions to manage and potentially mitigate the effects of HS (Sharma, 2018).<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"900\" height=\"473\" src=\"https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2023\/07\/Hidradenitis-Suppurativa-and-Genetics.webp\" alt=\"Hidradenitis Suppurativa and Genetics\" class=\"wp-image-5358\" srcset=\"https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2023\/07\/Hidradenitis-Suppurativa-and-Genetics.webp 900w, https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2023\/07\/Hidradenitis-Suppurativa-and-Genetics-300x158.webp 300w, https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2023\/07\/Hidradenitis-Suppurativa-and-Genetics-768x404.webp 768w, https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2023\/07\/Hidradenitis-Suppurativa-and-Genetics-696x366.webp 696w, https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2023\/07\/Hidradenitis-Suppurativa-and-Genetics-799x420.webp 799w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><figcaption class=\"wp-element-caption\">Hidradenitis Suppurativa and Genetics<\/figcaption><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"understanding-hs-and-genetics\"><strong>Understanding HS and Genetics<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"what-does-modern-science-say\"><strong>What Does Modern Science Say?<\/strong><\/h4>\n\n\n\n<p>Research indicates that genetics play a significant role in the development of HS. Studies show that approximately 30%-40% of individuals with HS have a family history of the condition, and specific genetic markers, such as mutations in the gamma-secretase complex, have been associated with HS. These mutations impair normal follicular function, leading to inflammation, abscess formation, and sinus tract development (Doe &amp; Smith, 2020).<\/p>\n\n\n\n<p>Key genetic factors include:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Familial Clustering:<\/strong> HS tends to run in families, particularly within first-degree relatives.<\/li>\n\n\n\n<li><strong>Autosomal Dominant Inheritance:<\/strong> Some cases of HS exhibit patterns consistent with this mode of inheritance.<\/li>\n\n\n\n<li><strong>Associated Conditions:<\/strong> Genetic predisposition to conditions like metabolic syndrome, Crohn&#8217;s disease, and polycystic ovary syndrome (PCOS) overlaps with HS, highlighting shared pathways (Gupta &amp; Singh, 2017).<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"ayurvedic-perspective-on-genetics\"><strong>Ayurvedic Perspective on Genetics<\/strong><\/h4>\n\n\n\n<p>Ayurveda views genetics through the lens of <strong>Beeja (seed)<\/strong> and <strong>Beejabhaga (genetic material)<\/strong>. Imbalances or deficiencies in the Beeja\u2014caused by poor parental health, lifestyle, or doshic imbalances\u2014can predispose individuals to specific conditions. HS, characterized by chronic inflammation, is seen as a result of inherited doshic tendencies, particularly <strong>Pitta-Kapha imbalances<\/strong> (Sharma, 2018).<\/p>\n\n\n\n<p><strong>Dr. Adil Moulanchikkal<\/strong>, Lead Specialist at EliteAyurveda, explains:<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>&#8220;In Ayurveda, genetics are not just about DNA; they reflect a cumulative karmic and environmental inheritance. Understanding and balancing these inherited tendencies is the key to managing conditions like HS.&#8221; (Moulanchikkal, 2023)<\/p>\n<\/blockquote>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"genetics-vs-environment-the-dual-impact\"><strong>Genetics vs. Environment: The Dual Impact<\/strong><\/h3>\n\n\n\n<p>While genetics lay the foundation, environmental factors often determine whether HS manifests. The interplay of inherited tendencies with lifestyle and external triggers highlights the need for a holistic approach.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th><strong>Aspect<\/strong><\/th><th><strong>Genetics<\/strong><\/th><th><strong>Environmental Triggers<\/strong><\/th><\/tr><\/thead><tbody><tr><td><strong>Role<\/strong><\/td><td>Provides susceptibility to HS.<\/td><td>Acts as a catalyst for symptom manifestation.<\/td><\/tr><tr><td><strong>Examples<\/strong><\/td><td>Family history, gene mutations.<\/td><td>Stress, diet, hormonal changes, hygiene.<\/td><\/tr><tr><td><strong>Ayurvedic Insight<\/strong><\/td><td>Inherited doshic imbalances.<\/td><td>Aggravation of Pitta and Kapha doshas.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"common-challenges-for-hs-patients-with-genetic-predisposition\"><strong>Common Challenges for HS Patients with Genetic Predisposition<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Misdiagnosis and Delayed Treatment:<\/strong><br>Familial clustering may lead to assumptions of shared lifestyle conditions rather than recognizing HS as a genetic disorder (Doe &amp; Smith, 2020).<\/li>\n\n\n\n<li><strong>Mental Health Impacts:<\/strong><br>Living with a chronic condition linked to family history often results in anxiety about passing it to future generations (Sharma, 2018).<\/li>\n\n\n\n<li><strong>Chronic Nature of Symptoms:<\/strong><br>Even with treatment, genetic predispositions can make achieving complete remission more challenging (Gupta &amp; Singh, 2017).<\/li>\n<\/ol>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"ayurvedic-approach-to-genetic-predisposition-in-hs\"><strong>Ayurvedic Approach to Genetic Predisposition in HS<\/strong><\/h3>\n\n\n\n<p>Ayurveda emphasizes <strong>holistic prevention and management<\/strong>, targeting both inherited and acquired imbalances. This approach is tailored to individual <em>Prakriti<\/em> (constitution) and <em>Vikruti<\/em> (current state of imbalance).<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"key-ayurvedic-strategies\"><strong>Key Ayurvedic Strategies:<\/strong><\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Balancing Doshic Imbalances<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>Pitta Management:<\/strong> Cooling therapies and anti-inflammatory herbs reduce inflammation (Chauhan, 2021).<\/li>\n\n\n\n<li><strong>Kapha Reduction:<\/strong> Detox therapies clear blockages in skin channels (<em>Swedovaha Srotas<\/em>) (Sharma, 2018).<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Detoxification Therapies<\/strong>\n<ul class=\"wp-block-list\">\n<li>Regular cleansing through <em>Panchakarma<\/em> to eliminate toxins (<em>Ama<\/em>) and improve immune modulation (Gupta &amp; Singh, 2017).<\/li>\n\n\n\n<li>Herbal teas and formulations to cleanse the lymphatic system.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Personalized Herbal Medications<\/strong>\n<ul class=\"wp-block-list\">\n<li>In-house formulations to address systemic inflammation without side effects.<\/li>\n\n\n\n<li>Focus on restoring cellular and immune balance to manage genetic predispositions (Sharma, 2018).<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Dietary Adjustments<\/strong>\n<ul class=\"wp-block-list\">\n<li>Anti-inflammatory and dosha-specific diets to prevent flare-ups.<\/li>\n\n\n\n<li>Avoiding Pitta-aggravating foods like spicy, fried, and acidic items (Chauhan, 2021).<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Lifestyle Modifications<\/strong>\n<ul class=\"wp-block-list\">\n<li>Incorporating stress-reducing practices like yoga, meditation, and <em>Pranayama<\/em>.<\/li>\n\n\n\n<li>Establishing consistent routines to balance circadian rhythms and improve immunity (Sharma, 2018).<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"ayurvedic-viewpoint-on-generational-healing\"><strong>Ayurvedic Viewpoint on Generational Healing<\/strong><\/h3>\n\n\n\n<p>Ayurveda believes that inherited tendencies can be mitigated by modifying <em>Ahara<\/em> (diet), <em>Vihara<\/em> (lifestyle), and <em>Aushadha<\/em> (herbal treatments). By addressing these aspects, future generations can inherit a healthier <em>Beeja<\/em> (seed) (Gupta &amp; Singh, 2017).<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"comparison-modern-genetics-vs-ayurvedic-approach\"><strong>Comparison: Modern Genetics vs. Ayurvedic Approach<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th><strong>Aspect<\/strong><\/th><th><strong>Modern Genetics<\/strong><\/th><th><strong>Ayurveda<\/strong><\/th><\/tr><\/thead><tbody><tr><td><strong>Focus<\/strong><\/td><td>Identifying gene mutations and pathways.<\/td><td>Balancing inherited doshic imbalances.<\/td><\/tr><tr><td><strong>Management<\/strong><\/td><td>Symptom suppression with medications.<\/td><td>Holistic healing through detox and balance.<\/td><\/tr><tr><td><strong>Prevention<\/strong><\/td><td>Limited to genetic counseling.<\/td><td>Comprehensive lifestyle and diet changes.<\/td><\/tr><tr><td><strong>Philosophy<\/strong><\/td><td>Reductionist and molecular.<\/td><td>Integrative and systemic.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"why-choose-elite-ayurveda-for-hs\"><strong>Why Choose EliteAyurveda for HS?<\/strong><\/h3>\n\n\n\n<p>At <strong>EliteAyurveda<\/strong>, we provide a comprehensive, patient-centric approach to managing HS by combining modern genetic insights with Ayurvedic wisdom:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Root-Cause Treatment:<\/strong> We address inherited and acquired imbalances to provide long-term relief.<\/li>\n\n\n\n<li><strong>Personalized Care:<\/strong> Treatments are tailored to your unique constitution and genetic predispositions.<\/li>\n\n\n\n<li><strong>Proprietary Herbal Medications:<\/strong> Safe and effective formulations crafted in-house.<\/li>\n\n\n\n<li><strong>Experienced Leadership:<\/strong> With over 15 years of expertise, <strong>Dr. Adil Moulanchikkal<\/strong> leads a dedicated team specializing in chronic inflammatory conditions.<\/li>\n<\/ol>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"real-stories-of-transformation\"><strong>Real Stories of Transformation<\/strong><\/h3>\n\n\n\n<p><em>&#8220;HS runs in my family, and I always thought it was untreatable. After consulting EliteAyurveda, I started a personalized treatment plan that not only reduced my flare-ups but also improved my overall health. My confidence is back, and I no longer fear passing this condition to my children.&#8221;<\/em><br>\u2014 <strong>Aditi R., Bengaluru<\/strong> (EliteAyurveda, 2023)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"from-the-doctors-desk\"><strong>From the Doctor\u2019s Desk<\/strong><\/h3>\n\n\n\n<p>Dr. Adil Moulanchikkal shares:<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>&#8220;Genetics may load the gun, but lifestyle and environment pull the trigger. With Ayurveda, we not only manage symptoms but also reprogram inherited imbalances for long-term wellness.&#8221; (Moulanchikkal, 2023)<\/p>\n<\/blockquote>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"your-path-to-holistic-healing-starts-here\"><strong>Your Path to Holistic Healing Starts Here<\/strong><\/h3>\n\n\n\n<p>HS doesn&#8217;t have to dictate your life or your future. With Ayurveda, you can address genetic predispositions and take control of your health.<\/p>\n\n\n\n<p>\ud83d\udcde <strong>Contact us today:<\/strong> +91 8884722246<br>\ud83c\udf10 <strong>Visit us:<\/strong> <a href=\"http:\/\/www.eliteayurveda.com\">www.eliteayurveda.com<\/a><\/p>\n\n\n\n<p><strong>Embrace a future of balance and wellness with EliteAyurveda.<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"references\">References<\/h3>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Click here for References<\/summary>\n<p>1.Kevin Phan O.C., Saxon D. Smith Global prevalence of hidradenitis suppurativa and geographical variation\u2014systematic review and meta-analysis. Biomed. Dermatol. 2020;4:2. doi: 10.1186\/s41702-019-0052-0.\u00a0[<a href=\"https:\/\/doi.org\/10.1186\/s41702-019-0052-0\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Biomed.%20Dermatol.&amp;title=Smith%20Global%20prevalence%20of%20hidradenitis%20suppurativa%20and%20geographical%20variation%E2%80%94systematic%20review%20and%20meta-analysis&amp;author=O.C.%20Kevin%20Phan&amp;author=D.%20Saxon&amp;volume=4&amp;publication_year=2020&amp;pages=2&amp;doi=10.1186\/s41702-019-0052-0&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>2.Zouboulis C.C., Benhadou F., Byrd A.S., Chandran N.S., Giamarellos-Bourboulis E.J., Fabbrocini G., Frew J.W., Fujita H., Gonzalez-Lopez M.A., Guillem P., et al. What causes hidradenitis suppurativa ?\u201415 years after. Exp. Dermatol. 2020;29:1154\u20131170. doi: 10.1111\/exd.14214.\u00a0[<a href=\"https:\/\/doi.org\/10.1111\/exd.14214\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33058306\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Exp.%20Dermatol.&amp;title=What%20causes%20hidradenitis%20suppurativa%20?%E2%80%9415%20years%20after&amp;author=C.C.%20Zouboulis&amp;author=F.%20Benhadou&amp;author=A.S.%20Byrd&amp;author=N.S.%20Chandran&amp;author=E.J.%20Giamarellos-Bourboulis&amp;volume=29&amp;publication_year=2020&amp;pages=1154-1170&amp;pmid=33058306&amp;doi=10.1111\/exd.14214&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>3.Gasparic J., Theut Riis P., Jemec G.B. Recognizing syndromic hidradenitis suppurativa: A review of the literature. J. Eur. Acad. Dermatol. Venereol. 2017;31:1809\u20131816. doi: 10.1111\/jdv.14464.\u00a0[<a href=\"https:\/\/doi.org\/10.1111\/jdv.14464\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28696038\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.%20Eur.%20Acad.%20Dermatol.%20Venereol.&amp;title=Recognizing%20syndromic%20hidradenitis%20suppurativa:%20A%20review%20of%20the%20literature&amp;author=J.%20Gasparic&amp;author=P.%20Theut%20Riis&amp;author=G.B.%20Jemec&amp;volume=31&amp;publication_year=2017&amp;pages=1809-1816&amp;pmid=28696038&amp;doi=10.1111\/jdv.14464&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>4.Genovese G., Moltrasio C., Garcovich S., Marzano A.V. PAPA spectrum disorders. G. Ital. Dermatol. Venereol. 2020;155:542\u2013550. doi: 10.23736\/S0392-0488.20.06629-8.\u00a0[<a href=\"https:\/\/doi.org\/10.23736\/S0392-0488.20.06629-8\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32618443\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=G.%20Ital.%20Dermatol.%20Venereol.&amp;title=PAPA%20spectrum%20disorders&amp;author=G.%20Genovese&amp;author=C.%20Moltrasio&amp;author=S.%20Garcovich&amp;author=A.V.%20Marzano&amp;volume=155&amp;publication_year=2020&amp;pages=542-550&amp;pmid=32618443&amp;doi=10.23736\/S0392-0488.20.06629-8&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>5.Chen W., Ito T., Lin S.H., Song Z., Al-Khuzaei S., Jurik A.G., Plewig G. Does SAPHO syndrome exist in dermatology? J. Eur. Acad. Dermatol. Venereol. 2022;36:1501\u20131506. doi: 10.1111\/jdv.18172.\u00a0[<a href=\"https:\/\/doi.org\/10.1111\/jdv.18172\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35462435\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.%20Eur.%20Acad.%20Dermatol.%20Venereol.&amp;title=Does%20SAPHO%20syndrome%20exist%20in%20dermatology?&amp;author=W.%20Chen&amp;author=T.%20Ito&amp;author=S.H.%20Lin&amp;author=Z.%20Song&amp;author=S.%20Al-Khuzaei&amp;volume=36&amp;publication_year=2022&amp;pages=1501-1506&amp;pmid=35462435&amp;doi=10.1111\/jdv.18172&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>6.Vural S., Baumgartner M., Lichtner P., Eckstein G., Hariry H., Chen W.C., Ruzicka T., Melnik B., Plewig G., Wagner M., et al. Investigation of gamma secretase gene complex mutations in German population with Hidradenitis suppurativa designate a complex polygenic heritage. J. Eur. Acad. Dermatol. Venereol. 2021;35:1386\u20131392. doi: 10.1111\/jdv.17163.\u00a0[<a href=\"https:\/\/doi.org\/10.1111\/jdv.17163\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33559291\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.%20Eur.%20Acad.%20Dermatol.%20Venereol.&amp;title=Investigation%20of%20gamma%20secretase%20gene%20complex%20mutations%20in%20German%20population%20with%20Hidradenitis%20suppurativa%20designate%20a%20complex%20polygenic%20heritage&amp;author=S.%20Vural&amp;author=M.%20Baumgartner&amp;author=P.%20Lichtner&amp;author=G.%20Eckstein&amp;author=H.%20Hariry&amp;volume=35&amp;publication_year=2021&amp;pages=1386-1392&amp;pmid=33559291&amp;doi=10.1111\/jdv.17163&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>7.Marzano A.V., Genovese G., Moltrasio C., Tricarico P.M., Gratton R., Piaserico S., Garcovich S., Boniotto M., Brandao L., Moura R., et al. Whole-Exome Sequencing in 10 Unrelated Patients with Syndromic Hidradenitis Suppurativa: A Preliminary Step for a Genotype-Phenotype Correlation. Dermatology. 2022:1\u201310. doi: 10.1159\/000521263.\u00a0[<a href=\"https:\/\/doi.org\/10.1159\/000521263\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35034021\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Dermatology&amp;title=Whole-Exome%20Sequencing%20in%2010%20Unrelated%20Patients%20with%20Syndromic%20Hidradenitis%20Suppurativa:%20A%20Preliminary%20Step%20for%20a%20Genotype-Phenotype%20Correlation&amp;author=A.V.%20Marzano&amp;author=G.%20Genovese&amp;author=C.%20Moltrasio&amp;author=P.M.%20Tricarico&amp;author=R.%20Gratton&amp;publication_year=2022&amp;pages=1-10&amp;pmid=35034021&amp;doi=10.1159\/000521263&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>8.Wang B., Yang W., Wen W., Sun J., Su B., Liu B., Ma D., Lv D., Wen Y., Qu T., et al. Gamma-secretase gene mutations in familial acne inversa. Science. 2010;330:1065. doi: 10.1126\/science.1196284.\u00a0[<a href=\"https:\/\/doi.org\/10.1126\/science.1196284\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20929727\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Science&amp;title=Gamma-secretase%20gene%20mutations%20in%20familial%20acne%20inversa&amp;author=B.%20Wang&amp;author=W.%20Yang&amp;author=W.%20Wen&amp;author=J.%20Sun&amp;author=B.%20Su&amp;volume=330&amp;publication_year=2010&amp;pages=1065&amp;pmid=20929727&amp;doi=10.1126\/science.1196284&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>9.Wu J., Ge H., Fan Y., Zhen Q., Tang L., Sun L. Novel Mutation of the NCSTN Gene Identified in a Chinese Acne Inversa Family. Ann. Dermatol. 2020;32:237\u2013242. doi: 10.5021\/ad.2020.32.3.237.\u00a0[<a href=\"https:\/\/doi.org\/10.5021\/ad.2020.32.3.237\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7992621\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33911744\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Ann.%20Dermatol.&amp;title=Novel%20Mutation%20of%20the%20NCSTN%20Gene%20Identified%20in%20a%20Chinese%20Acne%20Inversa%20Family&amp;author=J.%20Wu&amp;author=H.%20Ge&amp;author=Y.%20Fan&amp;author=Q.%20Zhen&amp;author=L.%20Tang&amp;volume=32&amp;publication_year=2020&amp;pages=237-242&amp;pmid=33911744&amp;doi=10.5021\/ad.2020.32.3.237&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>10.Xiao X., He Y., Li C., Zhang X., Xu H., Wang B. Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through the Notch and phosphoinositide 3-kinase\/AKT signalling pathways. Br. J. Dermatol. 2016;174:522\u2013532. doi: 10.1111\/bjd.14223.\u00a0[<a href=\"https:\/\/doi.org\/10.1111\/bjd.14223\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26473517\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Br.%20J.%20Dermatol.&amp;title=Nicastrin%20mutations%20in%20familial%20acne%20inversa%20impact%20keratinocyte%20proliferation%20and%20differentiation%20through%20the%20Notch%20and%20phosphoinositide%203-kinase\/AKT%20signalling%20pathways&amp;author=X.%20Xiao&amp;author=Y.%20He&amp;author=C.%20Li&amp;author=X.%20Zhang&amp;author=H.%20Xu&amp;volume=174&amp;publication_year=2016&amp;pages=522-532&amp;pmid=26473517&amp;doi=10.1111\/bjd.14223&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>11.Miskinyte S., Nassif A., Merabtene F., Ungeheuer M.N., Join-Lambert O., Jais J.P., Hovnanian A. Nicastrin mutations in French families with hidradenitis suppurativa. J. Investig. Dermatol. 2012;132:1728\u20131730. doi: 10.1038\/jid.2012.23.\u00a0[<a href=\"https:\/\/doi.org\/10.1038\/jid.2012.23\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22358060\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.%20Investig.%20Dermatol.&amp;title=Nicastrin%20mutations%20in%20French%20families%20with%20hidradenitis%20suppurativa&amp;author=S.%20Miskinyte&amp;author=A.%20Nassif&amp;author=F.%20Merabtene&amp;author=M.N.%20Ungeheuer&amp;author=O.%20Join-Lambert&amp;volume=132&amp;publication_year=2012&amp;pages=1728-1730&amp;pmid=22358060&amp;doi=10.1038\/jid.2012.23&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>12.Pink A.E., Simpson M.A., Brice G.W., Smith C.H., Desai N., Mortimer P.S., Barker J.N., Trembath R.C. PSENEN and NCSTN mutations in familial hidradenitis suppurativa (Acne Inversa) J. Investig. Dermatol. 2011;131:1568\u20131570. doi: 10.1038\/jid.2011.42.\u00a0[<a href=\"https:\/\/doi.org\/10.1038\/jid.2011.42\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21412258\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.%20Investig.%20Dermatol.&amp;title=PSENEN%20and%20NCSTN%20mutations%20in%20familial%20hidradenitis%20suppurativa%20(Acne%20Inversa)&amp;author=A.E.%20Pink&amp;author=M.A.%20Simpson&amp;author=G.W.%20Brice&amp;author=C.H.%20Smith&amp;author=N.%20Desai&amp;volume=131&amp;publication_year=2011&amp;pages=1568-1570&amp;pmid=21412258&amp;doi=10.1038\/jid.2011.42&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>13.Pink A.E., Simpson M.A., Desai N., Dafou D., Hills A., Mortimer P., Smith C.H., Trembath R.C., Barker J.N.W. Mutations in the gamma-secretase genes NCSTN, PSENEN, and PSEN1 underlie rare forms of hidradenitis suppurativa (acne inversa) J. Investig. Dermatol. 2012;132:2459\u20132461. doi: 10.1038\/jid.2012.162.\u00a0[<a href=\"https:\/\/doi.org\/10.1038\/jid.2012.162\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22622421\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.%20Investig.%20Dermatol.&amp;title=Mutations%20in%20the%20gamma-secretase%20genes%20NCSTN,%20PSENEN,%20and%20PSEN1%20underlie%20rare%20forms%20of%20hidradenitis%20suppurativa%20(acne%20inversa)&amp;author=A.E.%20Pink&amp;author=M.A.%20Simpson&amp;author=N.%20Desai&amp;author=D.%20Dafou&amp;author=A.%20Hills&amp;volume=132&amp;publication_year=2012&amp;pages=2459-2461&amp;pmid=22622421&amp;doi=10.1038\/jid.2012.162&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>14.Ralser D.J., Basmanav F.B., Tafazzoli A., Wititsuwannakul J., Delker S., Danda S., Thiele H., Wolf S., Busch M., Pulimood S.A., et al. Mutations in gamma-secretase subunit-encoding PSENEN underlie Dowling-Degos disease associated with acne inversa. J. Clin. Investig. 2017;127:1485\u20131490. doi: 10.1172\/JCI90667.\u00a0[<a href=\"https:\/\/doi.org\/10.1172\/JCI90667\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5373890\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28287404\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.%20Clin.%20Investig.&amp;title=Mutations%20in%20gamma-secretase%20subunit-encoding%20PSENEN%20underlie%20Dowling-Degos%20disease%20associated%20with%20acne%20inversa&amp;author=D.J.%20Ralser&amp;author=F.B.%20Basmanav&amp;author=A.%20Tafazzoli&amp;author=J.%20Wititsuwannakul&amp;author=S.%20Delker&amp;volume=127&amp;publication_year=2017&amp;pages=1485-1490&amp;pmid=28287404&amp;doi=10.1172\/JCI90667&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>15.Saito N., Minami-Hori M., Nagahata H., Nozaki H., Iinuma S., Igawa S., Kanno K., Kishibe M., Kanazawa N., Ishida-Yamamoto A. Novel PSTPIP1 gene mutation in pyoderma gangrenosum, acne and suppurative hidradenitis syndrome. J. Dermatol. 2018;45:e213\u2013e214. doi: 10.1111\/1346-8138.14259.\u00a0[<a href=\"https:\/\/doi.org\/10.1111\/1346-8138.14259\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29575118\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.%20Dermatol.&amp;title=Novel%20PSTPIP1%20gene%20mutation%20in%20pyoderma%20gangrenosum,%20acne%20and%20suppurative%20hidradenitis%20syndrome&amp;author=N.%20Saito&amp;author=M.%20Minami-Hori&amp;author=H.%20Nagahata&amp;author=H.%20Nozaki&amp;author=S.%20Iinuma&amp;volume=45&amp;publication_year=2018&amp;pages=e213-e214&amp;pmid=29575118&amp;doi=10.1111\/1346-8138.14259&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>16.Marzano A.V., Trevisan V., Gattorno M., Ceccherini I., De Simone C., Crosti C. Pyogenic arthritis, pyoderma gangrenosum, acne, and hidradenitis suppurativa (PAPASH): A new autoinflammatory syndrome associated with a novel mutation of the PSTPIP1 gene. JAMA Dermatol. 2013;149:762\u2013764. doi: 10.1001\/jamadermatol.2013.2907.\u00a0[<a href=\"https:\/\/doi.org\/10.1001\/jamadermatol.2013.2907\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23571383\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=JAMA%20Dermatol.&amp;title=Pyogenic%20arthritis,%20pyoderma%20gangrenosum,%20acne,%20and%20hidradenitis%20suppurativa%20(PAPASH):%20A%20new%20autoinflammatory%20syndrome%20associated%20with%20a%20novel%20mutation%20of%20the%20PSTPIP1%20gene&amp;author=A.V.%20Marzano&amp;author=V.%20Trevisan&amp;author=M.%20Gattorno&amp;author=I.%20Ceccherini&amp;author=C.%20De%20Simone&amp;volume=149&amp;publication_year=2013&amp;pages=762-764&amp;pmid=23571383&amp;doi=10.1001\/jamadermatol.2013.2907&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>17.Calderon-Castrat X., Bancalari-Diaz D., Roman-Curto C., Romo-Melgar A., Amoros-Cerdan D., Alcaraz-Mas L.A., Fernandez-Lopez E., Canueto J. PSTPIP1 gene mutation in a pyoderma gangrenosum, acne and suppurative hidradenitis (PASH) syndrome. Br. J. Dermatol. 2016;175:194\u2013198. doi: 10.1111\/bjd.14383.\u00a0[<a href=\"https:\/\/doi.org\/10.1111\/bjd.14383\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26713508\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Br.%20J.%20Dermatol.&amp;title=PSTPIP1%20gene%20mutation%20in%20a%20pyoderma%20gangrenosum,%20acne%20and%20suppurative%20hidradenitis%20(PASH)%20syndrome&amp;author=X.%20Calderon-Castrat&amp;author=D.%20Bancalari-Diaz&amp;author=C.%20Roman-Curto&amp;author=A.%20Romo-Melgar&amp;author=D.%20Amoros-Cerdan&amp;volume=175&amp;publication_year=2016&amp;pages=194-198&amp;pmid=26713508&amp;doi=10.1111\/bjd.14383&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>18.Jfri A., Litvinov I.V., Netchiporouk E., O\u2019Brien E. Novel variants of MEFV and NOD2 genes in familial hidradenitis suppurativa: A case report. SAGE Open Med. Case Rep. 2020;8:2050313X20953113. doi: 10.1177\/2050313X20953113.\u00a0[<a href=\"https:\/\/doi.org\/10.1177\/2050313X20953113\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7522817\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33029352\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=SAGE%20Open%20Med.%20Case%20Rep.&amp;title=Novel%20variants%20of%20MEFV%20and%20NOD2%20genes%20in%20familial%20hidradenitis%20suppurativa:%20A%20case%20report&amp;author=A.%20Jfri&amp;author=I.V.%20Litvinov&amp;author=E.%20Netchiporouk&amp;author=E.%20O%E2%80%99Brien&amp;volume=8&amp;publication_year=2020&amp;pages=2050313X20953113&amp;pmid=33029352&amp;doi=10.1177\/2050313X20953113&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>19.Marzano A.V., Ceccherini I., Gattorno M., Fanoni D., Caroli F., Rusmini M., Grossi A., De Simone C., Borghi O.M., Meroni P.L., et al. Association of pyoderma gangrenosum, acne, and suppurative hidradenitis (PASH) shares genetic and cytokine profiles with other autoinflammatory diseases. Medicine. 2014;93:e187. doi: 10.1097\/MD.0000000000000187.\u00a0[<a href=\"https:\/\/doi.org\/10.1097\/MD.0000000000000187\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4602806\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25501066\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Medicine&amp;title=Association%20of%20pyoderma%20gangrenosum,%20acne,%20and%20suppurative%20hidradenitis%20(PASH)%20shares%20genetic%20and%20cytokine%20profiles%20with%20other%20autoinflammatory%20diseases&amp;author=A.V.%20Marzano&amp;author=I.%20Ceccherini&amp;author=M.%20Gattorno&amp;author=D.%20Fanoni&amp;author=F.%20Caroli&amp;volume=93&amp;publication_year=2014&amp;pages=e187&amp;pmid=25501066&amp;doi=10.1097\/MD.0000000000000187&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>20.Ornelas J., Sivamani R., Awasthi S. A Report of Two Patients with Darier Disease and Hidradenitis Suppurativa. Pediatr. Dermatol. 2016;33:e265\u2013e266. doi: 10.1111\/pde.12891.\u00a0[<a href=\"https:\/\/doi.org\/10.1111\/pde.12891\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27282829\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Pediatr.%20Dermatol.&amp;title=A%20Report%20of%20Two%20Patients%20with%20Darier%20Disease%20and%20Hidradenitis%20Suppurativa&amp;author=J.%20Ornelas&amp;author=R.%20Sivamani&amp;author=S.%20Awasthi&amp;volume=33&amp;publication_year=2016&amp;pages=e265-e266&amp;pmid=27282829&amp;doi=10.1111\/pde.12891&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>21.Higgins R., Pink A., Hunger R., Yawalkar N., Navarini A.A. Generalized Comedones, Acne, and Hidradenitis Suppurativa in a Patient with an FGFR2 Missense Mutation. Front. Med. 2017;4:16. doi: 10.3389\/fmed.2017.00016.\u00a0[<a href=\"https:\/\/doi.org\/10.3389\/fmed.2017.00016\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5328982\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28293556\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front.%20Med.&amp;title=Generalized%20Comedones,%20Acne,%20and%20Hidradenitis%20Suppurativa%20in%20a%20Patient%20with%20an%20FGFR2%20Missense%20Mutation&amp;author=R.%20Higgins&amp;author=A.%20Pink&amp;author=R.%20Hunger&amp;author=N.%20Yawalkar&amp;author=A.A.%20Navarini&amp;volume=4&amp;publication_year=2017&amp;pages=16&amp;pmid=28293556&amp;doi=10.3389\/fmed.2017.00016&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>22.Maintz L., Betz R.C., Allam J.P., Wenzel J., Jaksche A., Friedrichs N., Bieber T., Novak N. Keratitis-ichthyosis-deafness syndrome in association with follicular occlusion triad. Eur. J. Dermatol. 2005;15:347\u2013352.\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16172043\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Eur.%20J.%20Dermatol.&amp;title=Keratitis-ichthyosis-deafness%20syndrome%20in%20association%20with%20follicular%20occlusion%20triad&amp;author=L.%20Maintz&amp;author=R.C.%20Betz&amp;author=J.P.%20Allam&amp;author=J.%20Wenzel&amp;author=A.%20Jaksche&amp;volume=15&amp;publication_year=2005&amp;pages=347-352&amp;pmid=16172043&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>23.Pedraz J., Penas P.F., Garcia-Diez A. Pachyonychia congenita and hidradenitis suppurativa: No response to infliximab therapy. J. Eur. Acad. Dermatol. Venereol. 2008;22:1500\u20131501. doi: 10.1111\/j.1468-3083.2008.02691.x.\u00a0[<a href=\"https:\/\/doi.org\/10.1111\/j.1468-3083.2008.02691.x\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18482325\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.%20Eur.%20Acad.%20Dermatol.%20Venereol.&amp;title=Pachyonychia%20congenita%20and%20hidradenitis%20suppurativa:%20No%20response%20to%20infliximab%20therapy&amp;author=J.%20Pedraz&amp;author=P.F.%20Penas&amp;author=A.%20Garcia-Diez&amp;volume=22&amp;publication_year=2008&amp;pages=1500-1501&amp;pmid=18482325&amp;doi=10.1111\/j.1468-3083.2008.02691.x&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>24.Marzuillo P., Piccolo V., Mascolo M., Apicella A., Argenziano G., Della Vecchia N., Guarino S., Miraglia Del Giudice E., La Manna A. Patients affected by dent disease 2 could be predisposed to hidradenitis suppurativa. J. Eur. Acad. Dermatol. Venereol. 2018;32:e309\u2013e311. doi: 10.1111\/jdv.14860.\u00a0[<a href=\"https:\/\/doi.org\/10.1111\/jdv.14860\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29430722\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.%20Eur.%20Acad.%20Dermatol.%20Venereol.&amp;title=Patients%20affected%20by%20dent%20disease%202%20could%20be%20predisposed%20to%20hidradenitis%20suppurativa&amp;author=P.%20Marzuillo&amp;author=V.%20Piccolo&amp;author=M.%20Mascolo&amp;author=A.%20Apicella&amp;author=G.%20Argenziano&amp;volume=32&amp;publication_year=2018&amp;pages=e309-e311&amp;pmid=29430722&amp;doi=10.1111\/jdv.14860&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>25.Basmanav F.B., Oprisoreanu A.M., Pasternack S.M., Thiele H., Fritz G., Wenzel J., Grosser L., Wehner M., Wolf S., Fagerberg C., et al. Mutations in POGLUT1, encoding protein O-glucosyltransferase 1, cause autosomal-dominant Dowling-Degos disease. Am. J. Hum. Genet. 2014;94:135\u2013143. doi: 10.1016\/j.ajhg.2013.12.003.\u00a0[<a href=\"https:\/\/doi.org\/10.1016\/j.ajhg.2013.12.003\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3882728\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24387993\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Am.%20J.%20Hum.%20Genet.&amp;title=Mutations%20in%20POGLUT1,%20encoding%20protein%20O-glucosyltransferase%201,%20cause%20autosomal-dominant%20Dowling-Degos%20disease&amp;author=F.B.%20Basmanav&amp;author=A.M.%20Oprisoreanu&amp;author=S.M.%20Pasternack&amp;author=H.%20Thiele&amp;author=G.%20Fritz&amp;volume=94&amp;publication_year=2014&amp;pages=135-143&amp;pmid=24387993&amp;doi=10.1016\/j.ajhg.2013.12.003&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n<\/details>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>Related-<\/strong><\/p>\n\n\n\n<p><a href=\"https:\/\/www.eliteayurveda.com\/diseases\/skin\/hidradenitis-suppurativa\/\" target=\"_blank\" rel=\"noreferrer noopener\">Know More About Ayurveda Treatment For Hidradenitis Suppurativa.<\/a><\/p>\n\n\n\n<div class=\"wp-block-group alignfull has-text-color has-background\" style=\"color:#000000;background-color:#ffffff\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div style=\"height:64px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center has-small-font-size\" style=\"line-height:.9\"><strong>GET IN TOUCH<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center\" id=\"schedule-a-visit\" style=\"font-size:59px;line-height:1.15\"><strong><a href=\"https:\/\/www.eliteayurveda.com\/contact-us\/#app\" target=\"_blank\" rel=\"noreferrer noopener\">Schedule a Visit<\/a><\/strong><\/h2>\n\n\n\n<div class=\"wp-block-buttons is-horizontal is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-499968f5 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-50\"><a class=\"wp-block-button__link has-text-color has-background wp-element-button\" href=\"https:\/\/www.eliteayurveda.com\/contact-us\/#app\" style=\"border-radius:50px;color:#ffffff;background-color:#000000\" target=\"_blank\" rel=\"noreferrer noopener\">Contact us<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:64px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The Relationship Between Hidradenitis Suppurativa and Genetics: An Ayurvedic Perspective Hidradenitis Suppurativa (HS), a chronic inflammatory skin condition, is not merely a disease of the skin but a systemic disorder with deeper roots. One of the most debated aspects of HS is its genetic predisposition. While Western medicine highlights genetic markers and familial clustering, Ayurveda [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5358,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"tdm_status":"","tdm_grid_status":"","footnotes":""},"categories":[76],"tags":[],"class_list":{"0":"post-2896","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-skin"},"_links":{"self":[{"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/posts\/2896","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/comments?post=2896"}],"version-history":[{"count":2,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/posts\/2896\/revisions"}],"predecessor-version":[{"id":5359,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/posts\/2896\/revisions\/5359"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/media\/5358"}],"wp:attachment":[{"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/media?parent=2896"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/categories?post=2896"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/tags?post=2896"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}