{"id":3510,"date":"2024-02-19T13:37:28","date_gmt":"2024-02-19T08:07:28","guid":{"rendered":"https:\/\/eliteayurveda.com\/blog\/?p=3510"},"modified":"2024-11-06T15:11:54","modified_gmt":"2024-11-06T09:41:54","slug":"ayurvedas-view-on-the-microbiome-and-its-role-in-crohns-disease","status":"publish","type":"post","link":"https:\/\/eliteayurveda.com\/blog\/ayurvedas-view-on-the-microbiome-and-its-role-in-crohns-disease\/","title":{"rendered":"Ayurveda&#8217;s View on the Microbiome and Its Role in Crohn&#8217;s Disease"},"content":{"rendered":"\n<p><strong>Ayurveda&#8217;s View on the Microbiome and Its Role in Crohn&#8217;s Disease<\/strong><\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>Table of Contents<\/h2><nav><ul><li><a href=\"#understanding-the-microbiome-in-ayurveda-agni-ama-and-dosha-balance\">Understanding the Microbiome in Ayurveda: Agni, Ama, and Dosha Balance<\/a><\/li><li><a href=\"#the-microbiome-and-crohns-disease-through-an-ayurvedic-lens\">The Microbiome and Crohn\u2019s Disease Through an Ayurvedic Lens<\/a><ul><li><a href=\"#1-weakened-agni-and-microbial-imbalance\">1. Weakened Agni and Microbial Imbalance<\/a><\/li><li><a href=\"#2-ama-and-dysbiosis\">2. Ama and Dysbiosis<\/a><\/li><li><a href=\"#3-doshic-imbalances-and-their-impact-on-gut-health\">3. Doshic Imbalances and Their Impact on Gut Health<\/a><\/li><\/ul><\/li><li><a href=\"#elite-ayurvedas-approach-to-managing-crohns-disease-through-microbiome-health\">EliteAyurveda\u2019s Approach to Managing Crohn\u2019s Disease Through Microbiome Health<\/a><ul><li><a href=\"#1-customized-diet-for-digestive-balance-and-microbiome-health\">1. Customized Diet for Digestive Balance and Microbiome Health<\/a><\/li><li><a href=\"#2-personalized-side-effect-free-ayurvedic-herbal-medications\">2. Personalized, Side-Effect-Free Ayurvedic Herbal Medications<\/a><\/li><li><a href=\"#3-daily-routine-dinacharya-for-gut-health-and-immune-stability\">3. Daily Routine (Dinacharya) for Gut Health and Immune Stability<\/a><\/li><li><a href=\"#4-mind-body-practices-for-stress-reduction\">4. Mind-Body Practices for Stress Reduction<\/a><\/li><li><a href=\"#5-seasonal-adjustments-for-microbial-and-digestive-stability\">5. Seasonal Adjustments for Microbial and Digestive Stability<\/a><\/li><\/ul><\/li><li><a href=\"#long-term-benefits-of-ayurvedic-management-of-crohns-disease\">Long-Term Benefits of Ayurvedic Management of Crohn\u2019s Disease<\/a><\/li><li><a href=\"#why-choose-elite-ayurveda-for-managing-crohns-disease\">Why Choose EliteAyurveda for Managing Crohn\u2019s Disease?<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<p>Crohn&#8217;s disease is a complex, chronic inflammatory bowel disease (IBD) characterized by inflammation along the digestive tract, which can lead to symptoms like abdominal pain, diarrhea, fatigue, and nutrient deficiencies (Baumgart &amp; Sandborn, 2012). Modern science links Crohn\u2019s disease to immune dysregulation and microbial imbalances in the gut, often described as &#8220;dysbiosis&#8221; (Frank et al., 2007). Ayurveda, while not directly referencing the microbiome, has long emphasized gut health, digestion, and toxin management as fundamental to overall wellness (Lad, 2002). EliteAyurveda\u2019s approach combines these Ayurvedic principles with the modern understanding of gut bacteria to support patients in managing Crohn\u2019s disease holistically (Sharma &amp; Chandola, 2011).<\/p>\n\n\n\n<div class=\"wp-block-cover\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim\"><\/span><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"338\" class=\"wp-block-cover__image-background wp-image-4976\" alt=\"Microbiome and Its Role in Crohn's Disease\" src=\"https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2024\/02\/668682f0e0749ef2a39a1474_65c64a25f7a2720e42d5d9d0_shutterstock_2221001821_MicrobiomeNewsPost202402.webp\" data-object-fit=\"cover\" srcset=\"https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2024\/02\/668682f0e0749ef2a39a1474_65c64a25f7a2720e42d5d9d0_shutterstock_2221001821_MicrobiomeNewsPost202402.webp 600w, https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2024\/02\/668682f0e0749ef2a39a1474_65c64a25f7a2720e42d5d9d0_shutterstock_2221001821_MicrobiomeNewsPost202402-300x169.webp 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<p class=\"has-text-align-center has-large-font-size\">Microbiome and Its Role in Crohn&#8217;s Disease<\/p>\n<\/div><\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"understanding-the-microbiome-in-ayurveda-agni-ama-and-dosha-balance\">Understanding the Microbiome in Ayurveda: Agni, Ama, and Dosha Balance<\/h3>\n\n\n\n<p>Ayurveda does not explicitly mention the microbiome but offers a deep understanding of gut health through concepts like <strong>Agni<\/strong> (digestive fire), <strong>Ama<\/strong> (toxins), and <strong>dosha<\/strong> balance (Frawley, 2000). These principles align closely with what we now know about the microbiome\u2019s influence on digestion, immunity, and inflammation (Peterson et al., 2015).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Agni (Digestive Fire):<\/strong> Agni represents the body\u2019s ability to digest food, absorb nutrients, and transform these into energy. When Agni is strong, it creates a healthy digestive environment that supports beneficial gut flora (Lad, 2002). In Crohn\u2019s disease, weak Agni can lead to poor digestion, nutrient malabsorption, and a disrupted gut environment, fostering harmful bacteria and inflammation (Sharma &amp; Chandola, 2011).<\/li>\n\n\n\n<li><strong>Ama (Toxins):<\/strong> Ama is the result of incomplete digestion and can accumulate in the digestive tract when Agni is weak. In Ayurveda, Ama represents toxic buildup that clogs the body\u2019s channels and disrupts natural processes, often correlating with dysbiosis in the gut (Mishra, 2004). Excess Ama creates an environment where inflammation can flourish, worsening Crohn\u2019s symptoms (Frawley, 2000).<\/li>\n\n\n\n<li><strong>Doshic Influence on Gut Health:<\/strong> The doshas\u2014<strong>Vata<\/strong>, <strong>Pitta<\/strong>, and <strong>Kapha<\/strong>\u2014each impact the digestive process and gut health uniquely. Imbalances in these doshas can disrupt the gut flora, impair Agni, and contribute to the development and severity of Crohn\u2019s symptoms (Pole, 2013).<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"the-microbiome-and-crohns-disease-through-an-ayurvedic-lens\">The Microbiome and Crohn\u2019s Disease Through an Ayurvedic Lens<\/h3>\n\n\n\n<p>In Ayurveda, Crohn\u2019s disease is seen as a result of weak digestive fire, toxic accumulation, and imbalances in the doshas, which disrupt the gut environment and weaken immunity (Lad, 2002). This perspective aligns with the modern understanding that microbial imbalances can lead to immune dysregulation and inflammation (Frank et al., 2007). Here\u2019s how Ayurveda interprets the microbiome\u2019s role in Crohn\u2019s disease:<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"1-weakened-agni-and-microbial-imbalance\">1. <strong>Weakened Agni and Microbial Imbalance<\/strong><\/h4>\n\n\n\n<p>In Crohn\u2019s disease, weak Agni often leads to improper digestion, creating fermentation, gas, and undigested food residues (Mishra, 2004). This undigested food encourages the growth of harmful bacteria, worsening symptoms and increasing gut inflammation (Peterson et al., 2015).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Ayurvedic Insight:<\/strong> Strengthening Agni through diet, herbal support, and lifestyle changes helps maintain a balanced gut environment where beneficial bacteria can thrive (Frawley, 2000). This, in turn, reduces inflammation and supports digestive health, addressing symptoms of Crohn\u2019s disease (Sharma &amp; Chandola, 2011).<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"2-ama-and-dysbiosis\">2. <strong>Ama and Dysbiosis<\/strong><\/h4>\n\n\n\n<p>Ama, or toxins resulting from incomplete digestion, disrupts gut health by creating a toxic environment that favors harmful bacteria and leads to dysbiosis (Mishra, 2004). In Crohn\u2019s disease, Ama accumulation contributes to inflammation, pain, and frequent flare-ups (Pole, 2013).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Ayurvedic Approach:<\/strong> Ayurveda emphasizes clearing Ama through detoxifying herbs and dietary modifications to improve digestion and support microbial balance (Lad, 2002). At EliteAyurveda, treatments focus on eliminating Ama, promoting a healthier gut environment, and reducing inflammation (Sharma &amp; Chandola, 2011).<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"3-doshic-imbalances-and-their-impact-on-gut-health\">3. <strong>Doshic Imbalances and Their Impact on Gut Health<\/strong><\/h4>\n\n\n\n<p>Each dosha affects digestion and the gut microbiome differently. For example:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Vata Imbalance:<\/strong> Vata governs movement and contributes to bloating, irregular bowel movements, and sensitivity in digestion (Frawley, 2000). When Vata is high, it can lead to erratic bowel patterns, cramps, and inflammation, all common in Crohn\u2019s disease (Lad, 2002).<\/li>\n\n\n\n<li><strong>Pitta Imbalance:<\/strong> Pitta controls metabolism and heat. When Pitta is aggravated, it can lead to excessive acid, inflammation, and heat, creating an environment of irritation and inflammation in the gut\u2014symptoms often seen in Crohn\u2019s disease (Pole, 2013).<\/li>\n\n\n\n<li><strong>Kapha Imbalance:<\/strong> Kapha governs structure and moisture. When Kapha is high, it can cause mucus buildup, sluggish digestion, and poor immune response (Dass, 2013). Kapha imbalances may lead to congestion and increased sensitivity in the digestive system (Mishra, 2004).<\/li>\n<\/ul>\n\n\n\n<p>At EliteAyurveda, our approach includes balancing these doshas to stabilize Agni and create a favorable environment for gut health, reducing symptoms and supporting overall well-being in Crohn\u2019s patients (Sharma &amp; Chandola, 2011).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"elite-ayurvedas-approach-to-managing-crohns-disease-through-microbiome-health\">EliteAyurveda\u2019s Approach to Managing Crohn\u2019s Disease Through Microbiome Health<\/h3>\n\n\n\n<p>EliteAyurveda\u2019s holistic approach to Crohn\u2019s disease incorporates Ayurvedic principles of digestion, detoxification, and doshic balance to promote a healthy gut environment and manage symptoms (Pole, 2013). Our treatments aim to strengthen Agni, reduce Ama, and maintain a balanced microbiome, using personalized herbal support and lifestyle guidance (Sharma &amp; Chandola, 2011).<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"1-customized-diet-for-digestive-balance-and-microbiome-health\">1. <strong>Customized Diet for Digestive Balance and Microbiome Health<\/strong><\/h4>\n\n\n\n<p>In Ayurveda, diet is central to managing doshic balance and supporting gut health (Lad, 2002). EliteAyurveda tailors dietary recommendations to each patient\u2019s constitution, doshic imbalance, and symptoms.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Pitta-Pacifying Foods:<\/strong> Crohn\u2019s disease often involves Pitta-related inflammation. Cooling foods like cucumbers, aloe vera, and leafy greens help calm inflammation and reduce heat in the gut (Frawley, 2000).<\/li>\n\n\n\n<li><strong>Vata-Stabilizing Foods:<\/strong> Warm, nourishing foods like soups, stews, and cooked grains provide grounding and hydration, helping to stabilize Vata and improve digestion (Dass, 2013).<\/li>\n\n\n\n<li><strong>Avoiding Kapha-Aggravating Foods:<\/strong> Foods that increase Kapha, such as dairy, fried foods, and heavy sugars, are avoided to prevent mucus buildup and digestive sluggishness (Mishra, 2004).<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"2-personalized-side-effect-free-ayurvedic-herbal-medications\">2. <strong>Personalized, Side-Effect-Free Ayurvedic Herbal Medications<\/strong><\/h4>\n\n\n\n<p>Our Ayurvedic herbal treatments are tailored to each patient\u2019s needs, designed to reduce inflammation, cleanse Ama, and support a balanced microbiome without side effects (Sharma &amp; Chandola, 2011).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Targeted Herbal Support:<\/strong> Cooling and anti-inflammatory herbs reduce Pitta-related inflammation, while grounding herbs stabilize Vata and support regular bowel movements (Frawley, 2000). These personalized herbal remedies foster a balanced gut environment, supporting beneficial bacteria and reducing harmful microbes (Pole, 2013).<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"3-daily-routine-dinacharya-for-gut-health-and-immune-stability\">3. <strong>Daily Routine (Dinacharya) for Gut Health and Immune Stability<\/strong><\/h4>\n\n\n\n<p>A stable daily routine, or Dinacharya, helps maintain Agni and supports gut health (Lad, 2002). Regularity in meals, sleep, and exercise is essential for managing Crohn\u2019s disease and promoting a healthy microbiome (Dass, 2013).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Regular Meal Times:<\/strong> Eating at the same times each day strengthens Agni and improves digestion, reducing Ama accumulation (Mishra, 2004).<\/li>\n\n\n\n<li><strong>Gentle Movement and Yoga:<\/strong> Exercise helps improve digestion, support lymphatic drainage, and maintain immune health, all of which are beneficial for managing Crohn\u2019s disease (Pole, 2013).<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"4-mind-body-practices-for-stress-reduction\">4. <strong>Mind-Body Practices for Stress Reduction<\/strong><\/h4>\n\n\n\n<p>Chronic stress impacts gut health, weakens Agni, and disrupts the microbiome (Kasture et al., 2013). Ayurveda\u2019s mind-body approach helps manage stress, stabilizing immune responses and reducing the risk of flare-ups in Crohn\u2019s disease (Lad, 2002).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Meditation and Pranayama (Breathing Exercises):<\/strong> Mindfulness practices and breath control techniques like Nadi Shodhana (Alternate Nostril Breathing) help calm Vata and Pitta, supporting digestive health and promoting immune resilience (Frawley, 2000).<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"5-seasonal-adjustments-for-microbial-and-digestive-stability\">5. <strong>Seasonal Adjustments for Microbial and Digestive Stability<\/strong><\/h4>\n\n\n\n<p>Each season affects doshic balance differently, which impacts digestion and gut health (Pole, 2013). Adjusting lifestyle and diet according to the seasons helps stabilize doshic fluctuations and maintain a healthy microbiome (Lad, 2002).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Cooling Foods and Hydration for Summer:<\/strong> In warmer months, Pitta increases, so cooling foods, hydration, and avoiding heat exposure help maintain balance and prevent inflammation (Dass, 2013).<\/li>\n\n\n\n<li><strong>Warming, Nourishing Foods for Winter:<\/strong> In colder months, Vata rises, so warm, cooked meals and grounding practices support digestion and gut health (Mishra, 2004).<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"long-term-benefits-of-ayurvedic-management-of-crohns-disease\">Long-Term Benefits of Ayurvedic Management of Crohn\u2019s Disease<\/h3>\n\n\n\n<p>Ayurvedic care provides sustainable relief by addressing root causes, supporting gut health, and promoting overall balance (Sharma &amp; Chandola, 2011). Key long-term benefits include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Reduced Inflammation and Fewer Flare-Ups:<\/strong> Balancing doshas and reducing Ama minimizes immune reactivity and inflammation, leading to fewer Crohn\u2019s flare-ups (Lad, 2002).<\/li>\n\n\n\n<li><strong>Improved Digestion and Nutrient Absorption:<\/strong> By strengthening Agni and supporting a balanced microbiome, Ayurveda enhances digestion and nutrient absorption, reducing malabsorption and discomfort (Frawley, 2000).<\/li>\n\n\n\n<li><strong>Holistic Well-Being:<\/strong> Ayurveda\u2019s mind-body approach supports emotional stability, reduces stress, and promotes resilience, contributing to an improved quality of life for those with Crohn\u2019s disease (Kasture et al., 2013).<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"why-choose-elite-ayurveda-for-managing-crohns-disease\">Why Choose EliteAyurveda for Managing Crohn\u2019s Disease?<\/h3>\n\n\n\n<p>EliteAyurveda offers a personalized, holistic approach to managing Crohn\u2019s disease by addressing gut health, doshic balance, and the microbiome (Sharma &amp; Chandola, 2011). Our expert practitioners create individualized care plans with side-effect-free herbal medications, dietary guidance, and lifestyle recommendations to help patients experience natural, sustainable relief and improved digestive health (Pole, 2013).<\/p>\n\n\n\n<p>If you\u2019re seeking a balanced, Ayurvedic approach to managing Crohn\u2019s disease, EliteAyurveda provides compassionate, knowledgeable support for your healing journey (EliteAyurveda, n.d.).<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>Related-<\/strong><\/p>\n\n\n\n<p><a href=\"https:\/\/eliteayurveda.com\/diseases\/gastroenteric\/crohns-disease\/\">Know more about ayurveda treatments for Crohn\u2019s Disease<\/a><\/p>\n\n\n\n<p><strong>GET IN TOUCH<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"schedule-a-visit\"><strong><a href=\"https:\/\/www.eliteayurveda.com\/contact-us\/#\" target=\"_blank\" rel=\"noreferrer noopener\">Schedule a Visit<\/a><\/strong><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.eliteayurveda.com\/contact-us\/#\" target=\"_blank\" rel=\"noreferrer noopener\">Contact us<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>References<\/strong><\/p>\n\n\n\n<p>1.Le Berre C., Ananthakrishnan A.N., Danese S., Singh S., Peyrin-Biroulet L. Ulcerative Colitis and Crohn\u2019s Disease Have Similar Burden and Goals for Treatment. Clin. Gastroenterol. Hepatol. 2020;18:14\u201323. doi: 10.1016\/j.cgh.2019.07.005.\u00a0[<a href=\"https:\/\/doi.org\/10.1016\/j.cgh.2019.07.005\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31301452\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Clin.%20Gastroenterol.%20Hepatol.&amp;title=Ulcerative%20Colitis%20and%20Crohn%E2%80%99s%20Disease%20Have%20Similar%20Burden%20and%20Goals%20for%20Treatment&amp;author=C.%20Le%20Berre&amp;author=A.N.%20Ananthakrishnan&amp;author=S.%20Danese&amp;author=S.%20Singh&amp;author=L.%20Peyrin-Biroulet&amp;volume=18&amp;publication_year=2020&amp;pages=14-23&amp;pmid=31301452&amp;doi=10.1016\/j.cgh.2019.07.005&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>2.Ng S.C., Shi H.Y., Hamidi N., Underwood F.E., Tang W., Benchimol E.I., Panaccione R., Ghosh S., Wu J.C.Y., Chan F.K.L., et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies. Lancet. 2017;390:2769\u20132778. doi: 10.1016\/S0140-6736(17)32448-0.\u00a0[<a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(17)32448-0\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29050646\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Lancet&amp;title=Worldwide%20incidence%20and%20prevalence%20of%20inflammatory%20bowel%20disease%20in%20the%2021st%20century:%20A%20systematic%20review%20of%20population-based%20studies&amp;author=S.C.%20Ng&amp;author=H.Y.%20Shi&amp;author=N.%20Hamidi&amp;author=F.E.%20Underwood&amp;author=W.%20Tang&amp;volume=390&amp;publication_year=2017&amp;pages=2769-2778&amp;pmid=29050646&amp;doi=10.1016\/S0140-6736(17)32448-0&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>3.Roda G., Chien Ng S., Kotze P.G., Argollo M., Panaccione R., Spinelli A., Kaser A., Peyrin-Biroulet L., Danese S. Crohn\u2019s disease. Nat. Rev. Dis. Primers. 2020;6:22. doi: 10.1038\/s41572-020-0156-2.\u00a0[<a href=\"https:\/\/doi.org\/10.1038\/s41572-020-0156-2\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32242028\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Nat.%20Rev.%20Dis.%20Primers&amp;title=Crohn%E2%80%99s%20disease&amp;author=G.%20Roda&amp;author=S.%20Chien%20Ng&amp;author=P.G.%20Kotze&amp;author=M.%20Argollo&amp;author=R.%20Panaccione&amp;volume=6&amp;publication_year=2020&amp;pages=22&amp;pmid=32242028&amp;doi=10.1038\/s41572-020-0156-2&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>4.Boyapati R., Satsangi J., Ho G.T. Pathogenesis of Crohn\u2019s disease. F1000Prime Rep. 2015;7:44. doi: 10.12703\/P7-44.\u00a0[<a href=\"https:\/\/doi.org\/10.12703\/P7-44\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4447044\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26097717\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=F1000Prime%20Rep.&amp;title=Pathogenesis%20of%20Crohn%E2%80%99s%20disease&amp;author=R.%20Boyapati&amp;author=J.%20Satsangi&amp;author=G.T.%20Ho&amp;volume=7&amp;publication_year=2015&amp;pages=44&amp;pmid=26097717&amp;doi=10.12703\/P7-44&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>5.Wilkins T., Jarvis K., Patel J. Diagnosis and management of Crohn\u2019s disease. Am. Fam. Phys. 2011;84:1365\u20131375.\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22230271\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Am.%20Fam.%20Phys.&amp;title=Diagnosis%20and%20management%20of%20Crohn%E2%80%99s%20disease&amp;author=T.%20Wilkins&amp;author=K.%20Jarvis&amp;author=J.%20Patel&amp;volume=84&amp;publication_year=2011&amp;pages=1365-1375&amp;pmid=22230271&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>6.Feuerstein J.D., Cheifetz A.S. Crohn Disease: Epidemiology, Diagnosis, and Management. Mayo Clin. Proc. 2017;92:1088\u20131103. doi: 10.1016\/j.mayocp.2017.04.010.\u00a0[<a href=\"https:\/\/doi.org\/10.1016\/j.mayocp.2017.04.010\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28601423\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Mayo%20Clin.%20Proc.&amp;title=Crohn%20Disease:%20Epidemiology,%20Diagnosis,%20and%20Management&amp;author=J.D.%20Feuerstein&amp;author=A.S.%20Cheifetz&amp;volume=92&amp;publication_year=2017&amp;pages=1088-1103&amp;pmid=28601423&amp;doi=10.1016\/j.mayocp.2017.04.010&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>7.Torres J., Mehandru S., Colombel J.F., Peyrin-Biroulet L. Crohn\u2019s disease. Lancet. 2017;389:1741\u20131755. doi: 10.1016\/S0140-6736(16)31711-1.\u00a0[<a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(16)31711-1\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27914655\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Lancet&amp;title=Crohn%E2%80%99s%20disease&amp;author=J.%20Torres&amp;author=S.%20Mehandru&amp;author=J.F.%20Colombel&amp;author=L.%20Peyrin-Biroulet&amp;volume=389&amp;publication_year=2017&amp;pages=1741-1755&amp;pmid=27914655&amp;doi=10.1016\/S0140-6736(16)31711-1&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>8.Ruemmele F.M., Veres G., Kolho K.L., Griffiths A., Levine A., Escher J.C., Amil Dias J., Barabino A., Braegger C.P., Bronsky J., et al. Consensus guidelines of ECCO\/ESPGHAN on the medical management of pediatric Crohn\u2019s disease. J. Crohns Colitis. 2014;8:1179\u20131207. doi: 10.1016\/j.crohns.2014.04.005.\u00a0[<a href=\"https:\/\/doi.org\/10.1016\/j.crohns.2014.04.005\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24909831\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.%20Crohns%20Colitis&amp;title=Consensus%20guidelines%20of%20ECCO\/ESPGHAN%20on%20the%20medical%20management%20of%20pediatric%20Crohn%E2%80%99s%20disease&amp;author=F.M.%20Ruemmele&amp;author=G.%20Veres&amp;author=K.L.%20Kolho&amp;author=A.%20Griffiths&amp;author=A.%20Levine&amp;volume=8&amp;publication_year=2014&amp;pages=1179-1207&amp;pmid=24909831&amp;doi=10.1016\/j.crohns.2014.04.005&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>9.Forbes A., Escher J., Hebuterne X., Klek S., Krznaric Z., Schneider S., Shamir R., Stardelova K., Wierdsma N., Wiskin A.E., et al. ESPEN guideline: Clinical nutrition in inflammatory bowel disease. Clin. Nutr. 2017;36:321\u2013347. doi: 10.1016\/j.clnu.2016.12.027.\u00a0[<a href=\"https:\/\/doi.org\/10.1016\/j.clnu.2016.12.027\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28131521\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Clin.%20Nutr.&amp;title=ESPEN%20guideline:%20Clinical%20nutrition%20in%20inflammatory%20bowel%20disease&amp;author=A.%20Forbes&amp;author=J.%20Escher&amp;author=X.%20Hebuterne&amp;author=S.%20Klek&amp;author=Z.%20Krznaric&amp;volume=36&amp;publication_year=2017&amp;pages=321-347&amp;pmid=28131521&amp;doi=10.1016\/j.clnu.2016.12.027&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>10.Ashton J.J., Gavin J., Beattie R.M. Exclusive enteral nutrition in Crohn\u2019s disease: Evidence and practicalities. Clin. Nutr. 2019;38:80\u201389. doi: 10.1016\/j.clnu.2018.01.020.\u00a0[<a href=\"https:\/\/doi.org\/10.1016\/j.clnu.2018.01.020\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29398336\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Clin.%20Nutr.&amp;title=Exclusive%20enteral%20nutrition%20in%20Crohn%E2%80%99s%20disease:%20Evidence%20and%20practicalities&amp;author=J.J.%20Ashton&amp;author=J.%20Gavin&amp;author=R.M.%20Beattie&amp;volume=38&amp;publication_year=2019&amp;pages=80-89&amp;pmid=29398336&amp;doi=10.1016\/j.clnu.2018.01.020&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>11.Milani C., Duranti S., Bottacini F., Casey E., Turroni F., Mahony J., Belzer C., Delgado Palacio S., Arboleya Montes S., Mancabelli L., et al. The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota. Microbiol. Mol. Biol. Rev. 2017;81:e00036-17. doi: 10.1128\/MMBR.00036-17.\u00a0[<a href=\"https:\/\/doi.org\/10.1128\/MMBR.00036-17\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5706746\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29118049\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Microbiol.%20Mol.%20Biol.%20Rev.&amp;title=The%20First%20Microbial%20Colonizers%20of%20the%20Human%20Gut:%20Composition,%20Activities,%20and%20Health%20Implications%20of%20the%20Infant%20Gut%20Microbiota&amp;author=C.%20Milani&amp;author=S.%20Duranti&amp;author=F.%20Bottacini&amp;author=E.%20Casey&amp;author=F.%20Turroni&amp;volume=81&amp;publication_year=2017&amp;pages=e00036-17&amp;pmid=29118049&amp;doi=10.1128\/MMBR.00036-17&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>12.Dinan T.G., Cryan J.F. Gut instincts: Microbiota as a key regulator of brain development, ageing and neurodegeneration. J. Physiol. 2017;595:489\u2013503. doi: 10.1113\/JP273106.\u00a0[<a href=\"https:\/\/doi.org\/10.1113\/JP273106\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5233671\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27641441\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.%20Physiol.&amp;title=Gut%20instincts:%20Microbiota%20as%20a%20key%20regulator%20of%20brain%20development,%20ageing%20and%20neurodegeneration&amp;author=T.G.%20Dinan&amp;author=J.F.%20Cryan&amp;volume=595&amp;publication_year=2017&amp;pages=489-503&amp;pmid=27641441&amp;doi=10.1113\/JP273106&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>13.Takiishi T., Fenero C.I.M., Camara N.O.S. Intestinal barrier and gut microbiota: Shaping our immune responses throughout life. Tissue Barriers. 2017;5:e1373208. doi: 10.1080\/21688370.2017.1373208.\u00a0[<a href=\"https:\/\/doi.org\/10.1080\/21688370.2017.1373208\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5788425\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28956703\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Tissue%20Barriers&amp;title=Intestinal%20barrier%20and%20gut%20microbiota:%20Shaping%20our%20immune%20responses%20throughout%20life&amp;author=T.%20Takiishi&amp;author=C.I.M.%20Fenero&amp;author=N.O.S.%20Camara&amp;volume=5&amp;publication_year=2017&amp;pages=e1373208&amp;pmid=28956703&amp;doi=10.1080\/21688370.2017.1373208&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>14.Carding S., Verbeke K., Vipond D.T., Corfe B.M., Owen L.J. Dysbiosis of the gut microbiota in disease. Microb. Ecol. Health Dis. 2015;26:26191. doi: 10.3402\/mehd.v26.26191.\u00a0[<a href=\"https:\/\/doi.org\/10.3402\/mehd.v26.26191\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4315779\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25651997\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Microb.%20Ecol.%20Health%20Dis.&amp;title=Dysbiosis%20of%20the%20gut%20microbiota%20in%20disease&amp;author=S.%20Carding&amp;author=K.%20Verbeke&amp;author=D.T.%20Vipond&amp;author=B.M.%20Corfe&amp;author=L.J.%20Owen&amp;volume=26&amp;publication_year=2015&amp;pages=26191&amp;pmid=25651997&amp;doi=10.3402\/mehd.v26.26191&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>15.Nell S., Suerbaum S., Josenhans C. The impact of the microbiota on the pathogenesis of IBD: Lessons from mouse infection models. Nat. Rev. Microbiol. 2010;8:564\u2013577. doi: 10.1038\/nrmicro2403.\u00a0[<a href=\"https:\/\/doi.org\/10.1038\/nrmicro2403\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20622892\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Nat.%20Rev.%20Microbiol.&amp;title=The%20impact%20of%20the%20microbiota%20on%20the%20pathogenesis%20of%20IBD:%20Lessons%20from%20mouse%20infection%20models&amp;author=S.%20Nell&amp;author=S.%20Suerbaum&amp;author=C.%20Josenhans&amp;volume=8&amp;publication_year=2010&amp;pages=564-577&amp;pmid=20622892&amp;doi=10.1038\/nrmicro2403&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>16.Oka A., Sartor R.B. Microbial-Based and Microbial-Targeted Therapies for Inflammatory Bowel Diseases. Dig. Dis. Sci. 2020;65:757\u2013788. doi: 10.1007\/s10620-020-06090-z.\u00a0[<a href=\"https:\/\/doi.org\/10.1007\/s10620-020-06090-z\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7311927\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32006212\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Dig.%20Dis.%20Sci.&amp;title=Microbial-Based%20and%20Microbial-Targeted%20Therapies%20for%20Inflammatory%20Bowel%20Diseases&amp;author=A.%20Oka&amp;author=R.B.%20Sartor&amp;volume=65&amp;publication_year=2020&amp;pages=757-788&amp;pmid=32006212&amp;doi=10.1007\/s10620-020-06090-z&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>17.Thomas J.P., Modos D., Rushbrook S.M., Powell N., Korcsmaros T. The Emerging Role of Bile Acids in the Pathogenesis of Inflammatory Bowel Disease. Front. Immunol. 2022;13:829525. doi: 10.3389\/fimmu.2022.829525.\u00a0[<a href=\"https:\/\/doi.org\/10.3389\/fimmu.2022.829525\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8850271\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35185922\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front.%20Immunol.&amp;title=The%20Emerging%20Role%20of%20Bile%20Acids%20in%20the%20Pathogenesis%20of%20Inflammatory%20Bowel%20Disease&amp;author=J.P.%20Thomas&amp;author=D.%20Modos&amp;author=S.M.%20Rushbrook&amp;author=N.%20Powell&amp;author=T.%20Korcsmaros&amp;volume=13&amp;publication_year=2022&amp;pages=829525&amp;pmid=35185922&amp;doi=10.3389\/fimmu.2022.829525&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>18.Gevers D., Kugathasan S., Denson L.A., Vazquez-Baeza Y., Van Treuren W., Ren B., Schwager E., Knights D., Song S.J., Yassour M., et al. The treatment-naive microbiome in new-onset Crohn\u2019s disease. Cell Host Microbe. 2014;15:382\u2013392. doi: 10.1016\/j.chom.2014.02.005.\u00a0[<a href=\"https:\/\/doi.org\/10.1016\/j.chom.2014.02.005\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4059512\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24629344\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Cell%20Host%20Microbe&amp;title=The%20treatment-naive%20microbiome%20in%20new-onset%20Crohn%E2%80%99s%20disease&amp;author=D.%20Gevers&amp;author=S.%20Kugathasan&amp;author=L.A.%20Denson&amp;author=Y.%20Vazquez-Baeza&amp;author=W.%20Van%20Treuren&amp;volume=15&amp;publication_year=2014&amp;pages=382-392&amp;pmid=24629344&amp;doi=10.1016\/j.chom.2014.02.005&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>19.Khanna S., Raffals L.E. The Microbiome in Crohn\u2019s Disease: Role in Pathogenesis and Role of Microbiome Replacement Therapies. Gastroenterol. Clin. N. Am. 2017;46:481\u2013492. doi: 10.1016\/j.gtc.2017.05.004.\u00a0[<a href=\"https:\/\/doi.org\/10.1016\/j.gtc.2017.05.004\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28838410\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Gastroenterol.%20Clin.%20N.%20Am.&amp;title=The%20Microbiome%20in%20Crohn%E2%80%99s%20Disease:%20Role%20in%20Pathogenesis%20and%20Role%20of%20Microbiome%20Replacement%20Therapies&amp;author=S.%20Khanna&amp;author=L.E.%20Raffals&amp;volume=46&amp;publication_year=2017&amp;pages=481-492&amp;pmid=28838410&amp;doi=10.1016\/j.gtc.2017.05.004&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>20.Strober W., Fuss I., Mannon P. The fundamental basis of inflammatory bowel disease. J. Clin. Investig. 2007;117:514\u2013521. doi: 10.1172\/JCI30587.\u00a0[<a href=\"https:\/\/doi.org\/10.1172\/JCI30587\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1804356\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17332878\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.%20Clin.%20Investig.&amp;title=The%20fundamental%20basis%20of%20inflammatory%20bowel%20disease&amp;author=W.%20Strober&amp;author=I.%20Fuss&amp;author=P.%20Mannon&amp;volume=117&amp;publication_year=2007&amp;pages=514-521&amp;pmid=17332878&amp;doi=10.1172\/JCI30587&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>21.Linares R., Frances R., Gutierrez A., Juanola O. Bacterial Translocation as Inflammatory Driver in Crohn\u2019s Disease. Front. Cell Dev. Biol. 2021;9:703310. doi: 10.3389\/fcell.2021.703310.\u00a0[<a href=\"https:\/\/doi.org\/10.3389\/fcell.2021.703310\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8452966\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34557484\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front.%20Cell%20Dev.%20Biol.&amp;title=Bacterial%20Translocation%20as%20Inflammatory%20Driver%20in%20Crohn%E2%80%99s%20Disease&amp;author=R.%20Linares&amp;author=R.%20Frances&amp;author=A.%20Gutierrez&amp;author=O.%20Juanola&amp;volume=9&amp;publication_year=2021&amp;pages=703310&amp;pmid=34557484&amp;doi=10.3389\/fcell.2021.703310&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>22.Geremia A., Arancibia-Carcamo C.V., Fleming M.P., Rust N., Singh B., Mortensen N.J., Travis S.P., Powrie F. IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J. Exp. Med. 2011;208:1127\u20131133. doi: 10.1084\/jem.20101712.\u00a0[<a href=\"https:\/\/doi.org\/10.1084\/jem.20101712\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3173242\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21576383\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.%20Exp.%20Med.&amp;title=IL-23-responsive%20innate%20lymphoid%20cells%20are%20increased%20in%20inflammatory%20bowel%20disease&amp;author=A.%20Geremia&amp;author=C.V.%20Arancibia-Carcamo&amp;author=M.P.%20Fleming&amp;author=N.%20Rust&amp;author=B.%20Singh&amp;volume=208&amp;publication_year=2011&amp;pages=1127-1133&amp;pmid=21576383&amp;doi=10.1084\/jem.20101712&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>23.Schmitt H., Neurath M.F., Atreya R. Role of the IL23\/IL17 Pathway in Crohn\u2019s Disease. Front. Immunol. 2021;12:622934. doi: 10.3389\/fimmu.2021.622934.\u00a0[<a href=\"https:\/\/doi.org\/10.3389\/fimmu.2021.622934\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8042267\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33859636\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front.%20Immunol.&amp;title=Role%20of%20the%20IL23\/IL17%20Pathway%20in%20Crohn%E2%80%99s%20Disease&amp;author=H.%20Schmitt&amp;author=M.F.%20Neurath&amp;author=R.%20Atreya&amp;volume=12&amp;publication_year=2021&amp;pages=622934&amp;pmid=33859636&amp;doi=10.3389\/fimmu.2021.622934&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>24.Kamada N., Hisamatsu T., Okamoto S., Chinen H., Kobayashi T., Sato T., Sakuraba A., Kitazume M.T., Sugita A., Koganei K., et al. Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23\/IFN-gamma axis. J. Clin. Investig. 2008;118:2269\u20132280. doi: 10.1172\/JCI34610.\u00a0[<a href=\"https:\/\/doi.org\/10.1172\/JCI34610\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2391067\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18497880\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.%20Clin.%20Investig.&amp;title=Unique%20CD14%20intestinal%20macrophages%20contribute%20to%20the%20pathogenesis%20of%20Crohn%20disease%20via%20IL-23\/IFN-gamma%20axis&amp;author=N.%20Kamada&amp;author=T.%20Hisamatsu&amp;author=S.%20Okamoto&amp;author=H.%20Chinen&amp;author=T.%20Kobayashi&amp;volume=118&amp;publication_year=2008&amp;pages=2269-2280&amp;pmid=18497880&amp;doi=10.1172\/JCI34610&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ayurveda&#8217;s View on the Microbiome and Its Role in Crohn&#8217;s Disease Crohn&#8217;s disease is a complex, chronic inflammatory bowel disease (IBD) characterized by inflammation along the digestive tract, which can lead to symptoms like abdominal pain, diarrhea, fatigue, and nutrient deficiencies (Baumgart &amp; Sandborn, 2012). Modern science links Crohn\u2019s disease to immune dysregulation and microbial [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4976,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"tdm_status":"","tdm_grid_status":"","footnotes":""},"categories":[80],"tags":[],"class_list":{"0":"post-3510","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-general"},"_links":{"self":[{"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/posts\/3510","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/comments?post=3510"}],"version-history":[{"count":2,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/posts\/3510\/revisions"}],"predecessor-version":[{"id":4977,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/posts\/3510\/revisions\/4977"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/media\/4976"}],"wp:attachment":[{"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/media?parent=3510"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/categories?post=3510"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/tags?post=3510"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}