{"id":3521,"date":"2024-02-19T23:52:46","date_gmt":"2024-02-19T18:22:46","guid":{"rendered":"https:\/\/eliteayurveda.com\/blog\/?p=3521"},"modified":"2024-11-09T11:20:41","modified_gmt":"2024-11-09T05:50:41","slug":"pediatric-autoimmune-disorders-recognizing-and-managing-symptoms-in-children-with-ayurveda","status":"publish","type":"post","link":"https:\/\/eliteayurveda.com\/blog\/pediatric-autoimmune-disorders-recognizing-and-managing-symptoms-in-children-with-ayurveda\/","title":{"rendered":"Pediatric Autoimmune Disorders: Recognizing and Managing Symptoms in Children with Ayurveda"},"content":{"rendered":"\n<p><strong>Pediatric Autoimmune Disorders: Treating with Ayurveda<\/strong><\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>Table of Contents<\/h2><nav><ul><li><a href=\"#ayurvedas-perspective-on-pediatric-autoimmune-disorders\">Ayurveda\u2019s Perspective on Pediatric Autoimmune Disorders<\/a><\/li><li><a href=\"#key-ayurvedic-principles-for-treating-pediatric-autoimmune-disorders\">Key Ayurvedic Principles for Treating Pediatric Autoimmune Disorders<\/a><ul><li><a href=\"#1-agni-digestive-fire-and-immunity\">1. Agni (Digestive Fire) and Immunity<\/a><\/li><li><a href=\"#2-balancing-doshas-for-symptom-relief\">2. Balancing Doshas for Symptom Relief<\/a><\/li><li><a href=\"#3-reducing-ama-toxins-through-gentle-detoxification\">3. Reducing Ama (Toxins) Through Gentle Detoxification<\/a><\/li><\/ul><\/li><li><a href=\"#elite-ayurvedas-holistic-approach-to-pediatric-autoimmune-care\">EliteAyurveda\u2019s Holistic Approach to Pediatric Autoimmune Care<\/a><ul><li><a href=\"#1-dietary-guidance-for-immunity-and-digestive-health\">1. Dietary Guidance for Immunity and Digestive Health<\/a><\/li><li><a href=\"#2-personalized-side-effect-free-herbal-treatments\">2. Personalized, Side-Effect-Free Herbal Treatments<\/a><\/li><li><a href=\"#3-establishing-a-consistent-routine-dinacharya-for-stability\">3. Establishing a Consistent Routine (Dinacharya) for Stability<\/a><\/li><li><a href=\"#4-mind-body-practices-for-emotional-resilience\">4. Mind-Body Practices for Emotional Resilience<\/a><\/li><\/ul><\/li><li><a href=\"#the-long-term-benefits-of-ayurvedic-care-for-pediatric-autoimmune-disorders\">The Long-Term Benefits of Ayurvedic Care for Pediatric Autoimmune Disorders<\/a><\/li><li><a href=\"#why-choose-elite-ayurveda-for-pediatric-autoimmune-care\">Why Choose EliteAyurveda for Pediatric Autoimmune Care?<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<p>Autoimmune disorders, conditions where the immune system mistakenly attacks healthy cells, are on the rise in children, affecting their physical and emotional well-being. Conditions like juvenile arthritis, pediatric Crohn&#8217;s disease, and Type 1 diabetes present unique challenges in pediatric care. Ayurveda offers a gentle, natural approach to treating pediatric autoimmune disorders by addressing underlying imbalances, supporting immune function, and promoting long-term wellness (Pole, 2013). At EliteAyurveda, our approach to pediatric autoimmune care focuses on personalized, age-appropriate treatments that align with Ayurvedic principles, aiming to restore balance and improve quality of life for children (Sharma &amp; Chandola, 2011).<\/p>\n\n\n\n<div class=\"wp-block-cover\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim\"><\/span><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"640\" class=\"wp-block-cover__image-background wp-image-4985\" alt=\"Pediatric Autoimmune Disorders\" src=\"https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2024\/02\/tired-blog-post-photo-1080x675-1-1024x640.jpg\" data-object-fit=\"cover\" srcset=\"https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2024\/02\/tired-blog-post-photo-1080x675-1-1024x640.jpg 1024w, https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2024\/02\/tired-blog-post-photo-1080x675-1-300x188.jpg 300w, https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2024\/02\/tired-blog-post-photo-1080x675-1-768x480.jpg 768w, https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2024\/02\/tired-blog-post-photo-1080x675-1-696x435.jpg 696w, https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2024\/02\/tired-blog-post-photo-1080x675-1-1068x668.jpg 1068w, https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2024\/02\/tired-blog-post-photo-1080x675-1-672x420.jpg 672w, https:\/\/eliteayurveda.com\/blog\/wp-content\/uploads\/2024\/02\/tired-blog-post-photo-1080x675-1.jpg 1080w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<p class=\"has-text-align-center has-large-font-size\">Pediatric Autoimmune Disorders<\/p>\n<\/div><\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"ayurvedas-perspective-on-pediatric-autoimmune-disorders\">Ayurveda\u2019s Perspective on Pediatric Autoimmune Disorders<\/h3>\n\n\n\n<p>In Ayurveda, autoimmune disorders are understood as imbalances in the body\u2019s doshas\u2014<strong>Vata<\/strong>, <strong>Pitta<\/strong>, and <strong>Kapha<\/strong>\u2014combined with weakened <strong>Agni<\/strong> (digestive fire) and the accumulation of <strong>Ama<\/strong> (toxins) (Lad, 2002). Children have unique constitutions and sensitivities, so Ayurveda takes a gentle, supportive approach to address the specific needs of each child (Dass, 2013).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Vata Imbalance:<\/strong> Vata governs movement and is sensitive to change. Vata-related autoimmune symptoms in children may manifest as joint pain, nervousness, and irregular sleep (Frawley, 2000).<\/li>\n\n\n\n<li><strong>Pitta Imbalance:<\/strong> Pitta governs heat and metabolism, and its excess can cause inflammation, digestive issues, and irritability. Many pediatric autoimmune symptoms, such as inflammation and fever, reflect a Pitta imbalance (Pole, 2013).<\/li>\n\n\n\n<li><strong>Kapha Imbalance:<\/strong> Kapha is associated with structure and immunity. Kapha-related autoimmune symptoms can include mucus buildup, sluggishness, and immune hypersensitivity, impacting respiratory health and energy (Mishra, 2004).<\/li>\n<\/ul>\n\n\n\n<p>Ayurveda focuses on treating these imbalances, supporting a child\u2019s growth and immunity, and managing symptoms naturally. EliteAyurveda tailors care to each child\u2019s constitution, aiming to support long-term resilience and wellness (Sharma &amp; Chandola, 2011).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"key-ayurvedic-principles-for-treating-pediatric-autoimmune-disorders\">Key Ayurvedic Principles for Treating Pediatric Autoimmune Disorders<\/h3>\n\n\n\n<p>When treating pediatric autoimmune conditions, Ayurveda emphasizes a gentle approach that addresses root imbalances, supports immune function, and reduces the triggers of inflammation. Here\u2019s how Ayurveda views the core aspects of managing these conditions:<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"1-agni-digestive-fire-and-immunity\">1. <strong>Agni (Digestive Fire) and Immunity<\/strong><\/h4>\n\n\n\n<p>In Ayurveda, a strong Agni (digestive fire) is crucial for overall health and immunity. When Agni is weak, food is not fully digested, leading to the accumulation of Ama (toxins) that disrupts immune function and increases inflammation. This weakened digestion is often seen in pediatric autoimmune cases (Lad, 2002).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Ayurvedic Insight:<\/strong> Strengthening Agni with gentle digestive herbs, easy-to-digest foods, and regular mealtimes helps improve nutrient absorption, detoxifies the body, and supports a balanced immune response (Frawley, 2000). EliteAyurveda\u2019s approach emphasizes a diet that supports Agni without overburdening a child\u2019s sensitive digestive system.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"2-balancing-doshas-for-symptom-relief\">2. <strong>Balancing Doshas for Symptom Relief<\/strong><\/h4>\n\n\n\n<p>Each dosha affects the body differently, and Ayurvedic care focuses on addressing the dominant doshic imbalance to alleviate symptoms and restore harmony (Pole, 2013).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Vata-Pacifying Practices:<\/strong> For autoimmune symptoms with joint pain and sleep disturbances, calming Vata with warm, grounding foods and routines helps support physical comfort and emotional stability (Dass, 2013).<\/li>\n\n\n\n<li><strong>Pitta-Reducing Measures:<\/strong> For inflammatory conditions, such as juvenile arthritis, cooling foods and gentle, anti-inflammatory herbs help soothe Pitta and reduce pain and swelling (Lad, 2002).<\/li>\n\n\n\n<li><strong>Kapha-Balancing Adjustments:<\/strong> To manage respiratory symptoms or mucus buildup, light, warm foods and daily physical activity help prevent Kapha accumulation and improve energy levels (Mishra, 2004).<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"3-reducing-ama-toxins-through-gentle-detoxification\">3. <strong>Reducing Ama (Toxins) Through Gentle Detoxification<\/strong><\/h4>\n\n\n\n<p>Ama, or toxic buildup, can be especially challenging in pediatric autoimmune disorders. Unlike adults, children require very gentle detoxification to avoid stress on their systems. In Ayurveda, simple detox practices are used to reduce Ama and support immunity (Frawley, 2000).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Ayurvedic Approach:<\/strong> Detoxification methods for children focus on supporting Agni through light, easily digestible meals, warm teas, and mild detoxifying herbs (Pole, 2013). At EliteAyurveda, we design personalized detox plans that align with each child\u2019s constitution, helping eliminate toxins without disrupting their natural balance (Sharma &amp; Chandola, 2011).<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"elite-ayurvedas-holistic-approach-to-pediatric-autoimmune-care\">EliteAyurveda\u2019s Holistic Approach to Pediatric Autoimmune Care<\/h3>\n\n\n\n<p>At EliteAyurveda, we approach pediatric autoimmune care with an understanding of children\u2019s unique constitutions and developmental needs. Our treatments aim to nurture a child\u2019s innate healing capacity, strengthen immunity, and provide relief from symptoms through safe, side-effect-free care (Dass, 2013).<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"1-dietary-guidance-for-immunity-and-digestive-health\">1. <strong>Dietary Guidance for Immunity and Digestive Health<\/strong><\/h4>\n\n\n\n<p>Diet is one of the most powerful tools in Ayurveda, especially for supporting children\u2019s immunity and growth. EliteAyurveda provides age-appropriate dietary guidance that balances doshas, strengthens digestion, and minimizes inflammation (Lad, 2002).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Kapha-Balancing Foods:<\/strong> Light, warm foods such as soups, rice, and steamed vegetables help avoid congestion and support clear channels, reducing Kapha-related immune imbalances (Mishra, 2004).<\/li>\n\n\n\n<li><strong>Pitta-Pacifying Foods:<\/strong> Cooling, anti-inflammatory foods like cucumber, ghee, and apples help reduce inflammation and soothe Pitta-related symptoms (Frawley, 2000).<\/li>\n\n\n\n<li><strong>Vata-Stabilizing Foods:<\/strong> Warm, grounding foods, including oats, carrots, and sweet potatoes, provide Vata stability and comfort, helping manage joint discomfort and nervousness (Dass, 2013).<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"2-personalized-side-effect-free-herbal-treatments\">2. <strong>Personalized, Side-Effect-Free Herbal Treatments<\/strong><\/h4>\n\n\n\n<p>Our Ayurvedic herbal treatments are specifically tailored to suit children\u2019s sensitivities, supporting immune health, calming inflammation, and balancing doshas without adverse effects. Herbs are selected based on the child\u2019s constitution and specific needs (Pole, 2013).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Targeted Herbal Support:<\/strong> For example, gentle, cooling herbs help reduce inflammation for Pitta-predominant children, while grounding herbs stabilize Vata. EliteAyurveda\u2019s herbal formulations are designed to support the child\u2019s unique requirements, fostering natural resilience and supporting immune function (Lad, 2002).<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"3-establishing-a-consistent-routine-dinacharya-for-stability\">3. <strong>Establishing a Consistent Routine (Dinacharya) for Stability<\/strong><\/h4>\n\n\n\n<p>A consistent daily routine, or Dinacharya, provides stability, improves digestion, and helps children cope with the unpredictability of autoimmune conditions (Frawley, 2000). Ayurveda emphasizes regular schedules to balance Vata, support Agni, and enhance immunity.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Regular Sleep and Mealtimes:<\/strong> Consistent sleep and mealtimes help maintain Agni, balance doshas, and support overall resilience, which is especially important for children with autoimmune conditions (Pole, 2013).<\/li>\n\n\n\n<li><strong>Abhyanga (Self-Oil Massage):<\/strong> Daily oil massage using warm, dosha-specific oils like sesame or coconut helps ground the child\u2019s mind and body, providing comfort, enhancing circulation, and reducing dryness (Mishra, 2004).<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"4-mind-body-practices-for-emotional-resilience\">4. <strong>Mind-Body Practices for Emotional Resilience<\/strong><\/h4>\n\n\n\n<p>Living with an autoimmune condition can be emotionally challenging, even for children. Ayurveda emphasizes the connection between mind and body, incorporating mind-body practices to support mental and emotional well-being (Dass, 2013).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Gentle Yoga and Breathwork:<\/strong> Age-appropriate yoga poses and breathing exercises help children feel calm, grounded, and emotionally resilient, balancing Vata and Pitta and helping to reduce stress (Frawley, 2000).<\/li>\n\n\n\n<li><strong>Visualization and Meditation:<\/strong> Simple visualization exercises and short meditation practices can help children manage stress and foster a positive outlook, reducing the psychological toll of chronic illness (Sharma &amp; Chandola, 2011).<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"the-long-term-benefits-of-ayurvedic-care-for-pediatric-autoimmune-disorders\">The Long-Term Benefits of Ayurvedic Care for Pediatric Autoimmune Disorders<\/h3>\n\n\n\n<p>Ayurvedic care for pediatric autoimmune disorders provides sustainable, long-term benefits by addressing underlying imbalances, supporting immunity, and fostering emotional resilience. The holistic approach at EliteAyurveda benefits children with autoimmune conditions in multiple ways:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Reduced Flare-Ups and Symptom Severity:<\/strong> By balancing doshas, strengthening Agni, and reducing Ama, Ayurveda minimizes the likelihood of flare-ups and reduces symptom severity (Lad, 2002).<\/li>\n\n\n\n<li><strong>Enhanced Physical and Emotional Well-Being:<\/strong> Mind-body practices help children develop resilience, stay grounded, and reduce stress, improving their overall quality of life (Dass, 2013).<\/li>\n\n\n\n<li><strong>Improved Immune Function:<\/strong> Ayurveda\u2019s approach supports natural immunity, reducing dependency on medications and helping the child\u2019s body respond to environmental stressors more effectively (Pole, 2013).<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"why-choose-elite-ayurveda-for-pediatric-autoimmune-care\">Why Choose EliteAyurveda for Pediatric Autoimmune Care?<\/h3>\n\n\n\n<p>At EliteAyurveda, we understand that treating pediatric autoimmune conditions requires a compassionate, individualized approach that is sensitive to each child\u2019s constitution and needs (Sharma &amp; Chandola, 2011). Our experienced practitioners design care plans that include side-effect-free herbs, personalized dietary guidance, gentle detoxification, and lifestyle recommendations to support the child\u2019s holistic health. By focusing on root causes and promoting long-term resilience, we help children achieve lasting improvements in both physical and emotional well-being (Lad, 2002).<\/p>\n\n\n\n<p>If you\u2019re seeking a natural, Ayurvedic approach to pediatric autoimmune care, EliteAyurveda provides expert guidance and support tailored to your child\u2019s unique needs (EliteAyurveda, n.d.).<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>Related-<\/strong><\/p>\n\n\n\n<p><a href=\"https:\/\/eliteayurveda.com\/diseases\/autoimmune\/\">Know More Ayurveda Treatments For Autoimmune Conditions.<\/a><\/p>\n\n\n\n<p><strong>GET IN TOUCH<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"schedule-a-visit\"><strong><a href=\"https:\/\/www.eliteayurveda.com\/contact-us\/#\" target=\"_blank\" rel=\"noreferrer noopener\">Schedule a Visit<\/a><\/strong><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.eliteayurveda.com\/contact-us\/#\" target=\"_blank\" rel=\"noreferrer noopener\">Contact us<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>References<\/strong><\/p>\n\n\n\n<p>1.Pituch-Noworolska A, Mach-Tomalska M. Autoimmunity of gastrointestinal tract immunopathogenesis and immune-based therapy for selected autoimmune disorders. Mourad Aribi, ed. Intech Open March 22nd 2017. https:\/\/doi.org\/10.5772\/63032 10.5772\/63032\u00a0[<a href=\"https:\/\/doi.org\/10.5772\/63032\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Mourad%20Aribi,%20ed.%20Intech%20Open%20March%2022nd&amp;title=Autoimmunity%20of%20gastrointestinal%20tract%20immunopathogenesis%20and%20immune-based%20therapy%20for%20selected%20autoimmune%20disorders&amp;author=A%20Pituch-Noworolska&amp;author=M%20Mach-Tomalska&amp;publication_year=2017&amp;doi=10.5772\/63032&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>2.Cojocaru M, Cojocaru IM, Silosi I, et al. Gastrointestinal manifestations in systemic autoimmune diseases. Maedica (Bucur) 2011;6:45-51.\u00a0[<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3150032\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21977190\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Maedica%20(Bucur)&amp;title=Gastrointestinal%20manifestations%20in%20systemic%20autoimmune%20diseases&amp;author=M%20Cojocaru&amp;author=IM%20Cojocaru&amp;author=I%20Silosi&amp;volume=6&amp;publication_year=2011&amp;pages=45-51&amp;pmid=21977190&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>3.Unsworth DJ, Walker-Smith JA. Autoimmunity in diarrhoeal disease. J Pediatr Gastroenterol Nutr 1985;4:375-380. https:\/\/doi.org\/10.1097\/00005176-198506000-00009 10.1097\/00005176-198506000-00009\u00a0[<a href=\"https:\/\/doi.org\/10.1097\/00005176-198506000-00009\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/4020570\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J%20Pediatr%20Gastroenterol%20Nutr&amp;title=Autoimmunity%20in%20diarrhoeal%20disease&amp;author=DJ%20Unsworth&amp;author=JA%20Walker-Smith&amp;volume=4&amp;publication_year=1985&amp;pages=375-380&amp;pmid=4020570&amp;doi=10.1097\/00005176-198506000-00009&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>4.Ensari A, Kelsen J, Russo P. Newcomers in paediatric GI pathology: childhood enteropathies including very early onset monogenic IBD. Virchows Arch 2018;472:111-123. https:\/\/doi.org\/10.1007\/s00428-017-2197-9 10.1007\/s00428-017-2197-9\u00a0[<a href=\"https:\/\/doi.org\/10.1007\/s00428-017-2197-9\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6171108\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28718031\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Virchows%20Arch&amp;title=Newcomers%20in%20paediatric%20GI%20pathology:%20childhood%20enteropathies%20including%20very%20early%20onset%20monogenic%20IBD&amp;author=A%20Ensari&amp;author=J%20Kelsen&amp;author=P%20Russo&amp;volume=472&amp;publication_year=2018&amp;pages=111-123&amp;pmid=28718031&amp;doi=10.1007\/s00428-017-2197-9&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>5.Rossi C, Simoncelli G, Arpa G, et al. Histopathology of intestinal villi in neonatal and paediatric age: main features with clinical correlation Part I. Pathologica 2021. Epub December 2. https:\/\/doi.org\/10.32074\/1591-951X-337 10.32074\/1591-951X-337\u00a0[<a href=\"https:\/\/doi.org\/10.32074\/1591-951X-337\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9040547\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34856604\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Pathologica&amp;title=Histopathology%20of%20intestinal%20villi%20in%20neonatal%20and%20paediatric%20age:%20main%20features%20with%20clinical%20correlation%20Part%20I&amp;author=C%20Rossi&amp;author=G%20Simoncelli&amp;author=G%20Arpa&amp;publication_year=2021&amp;pmid=34856604&amp;doi=10.32074\/1591-951X-337&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>6.Russo PA, Brochu P, Seidman EG, et al. Autoimmune enteropathy. Pediatr Dev Pathol 1999;2:65-71. https:\/\/doi.org\/10.1007\/s100249900092 10.1007\/s100249900092\u00a0[<a href=\"https:\/\/doi.org\/10.1007\/s100249900092\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9841709\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Pediatr%20Dev%20Pathol&amp;title=Autoimmune%20enteropathy&amp;author=PA%20Russo&amp;author=P%20Brochu&amp;author=EG%20Seidman&amp;volume=2&amp;publication_year=1999&amp;pages=65-71&amp;pmid=9841709&amp;doi=10.1007\/s100249900092&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>7.Walker-Smith JA, Unsworth DJ, Hutchins P, et al. Autoantibodies against gut epithelium in child with small-intestinal enteropathy. Lancet 1982;1(8271):566-7. https:\/\/doi.org\/10.1016\/s0140-6736(82)92076-1 10.1016\/s0140-6736(82)92076-1\u00a0[<a href=\"https:\/\/doi.org\/10.1016\/s0140-6736(82)92076-1\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6120421\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Lancet&amp;title=Autoantibodies%20against%20gut%20epithelium%20in%20child%20with%20small-intestinal%20enteropathy&amp;author=JA%20Walker-Smith&amp;author=DJ%20Unsworth&amp;author=P%20Hutchins&amp;volume=1&amp;issue=8271&amp;publication_year=1982&amp;pages=566-7&amp;pmid=6120421&amp;doi=10.1016\/s0140-6736(82)92076-1&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>8.Skogh T, Heuman R, Tagesson C. Anti- brush border antibodies (ABBA) in Crohn\u2019s disease. J Clin Lab Immunol 1982;9:147-150.\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6762441\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J%20Clin%20Lab%20Immunol&amp;title=Anti-%20brush%20border%20antibodies%20(ABBA)%20in%20Crohn%E2%80%99s%20disease&amp;author=T%20Skogh&amp;author=R%20Heuman&amp;author=C%20Tagesson&amp;volume=9&amp;publication_year=1982&amp;pages=147-150&amp;pmid=6762441&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>9.Montalto M, D\u2019Onofrio F, Santoro L, et al. Autoimmune enteropathy in children and adults. Scand J Gastroenterol 2009;44:1029-1036. https:\/\/doi.org\/10.1080\/00365520902783691 10.1080\/00365520902783691\u00a0[<a href=\"https:\/\/doi.org\/10.1080\/00365520902783691\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19255930\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Scand%20J%20Gastroenterol&amp;title=Autoimmune%20enteropathy%20in%20children%20and%20adults&amp;author=M%20Montalto&amp;author=F%20D%E2%80%99Onofrio&amp;author=L%20Santoro&amp;volume=44&amp;publication_year=2009&amp;pages=1029-1036&amp;pmid=19255930&amp;doi=10.1080\/00365520902783691&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>10.Chen CB, Tahboub F, Plesec T, et al. A Review of autoimmune enteropathy and its associated syndromes. Dig Dis Sci 2020;65:3079-3090. https:\/\/doi.org\/10.1007\/s10620-020-06540-8 10.1007\/s10620-020-06540-8\u00a0[<a href=\"https:\/\/doi.org\/10.1007\/s10620-020-06540-8\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32833153\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Dig%20Dis%20Sci&amp;title=A%20Review%20of%20autoimmune%20enteropathy%20and%20its%20associated%20syndromes&amp;author=CB%20Chen&amp;author=F%20Tahboub&amp;author=T%20Plesec&amp;volume=65&amp;publication_year=2020&amp;pages=3079-3090&amp;pmid=32833153&amp;doi=10.1007\/s10620-020-06540-8&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>11.Parente P, Pastore M, Grillo F, et al. Very Early Onset-IBD: evidence for the need of a multidisciplinary approach. Pathologica 2021. Epub December 2. https:\/\/doi.org\/10.32074\/1591-951X-336 10.32074\/1591-951X-336\u00a0[<a href=\"https:\/\/doi.org\/10.32074\/1591-951X-336\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9040548\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34856603\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Pathologica&amp;title=Very%20Early%20Onset-IBD:%20evidence%20for%20the%20need%20of%20a%20multidisciplinary%20approach&amp;author=P%20Parente&amp;author=M%20Pastore&amp;author=F%20Grillo&amp;publication_year=2021&amp;pmid=34856603&amp;doi=10.32074\/1591-951X-336&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>12.Rossi C, Simoncelli G, Arpa G, et al. Histopathology of intestinal villi in neonatal and paediatric age: main features with clinical correlation Part II. Pathologica 2021. Epub December 2. https:\/\/doi.org\/10.32074\/1591-951X-338 10.32074\/1591-951X-338\u00a0[<a href=\"https:\/\/doi.org\/10.32074\/1591-951X-338\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9040547\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34856604\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Pathologica&amp;title=Histopathology%20of%20intestinal%20villi%20in%20neonatal%20and%20paediatric%20age:%20main%20features%20with%20clinical%20correlation%20Part%20II&amp;author=C%20Rossi&amp;author=G%20Simoncelli&amp;author=G%20Arpa&amp;publication_year=2021&amp;pmid=34856604&amp;doi=10.32074\/1591-951X-338&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>13.Biagi F, Bianchi PI, Trotta L, et al. Anti-goblet cell antibodies for the diagnosis of autoimmune enteropathy? Am J Gastroenterol 2009;104:3112. https:\/\/doi.org\/10.1038\/ajg.2009.511 10.1038\/ajg.2009.511\u00a0[<a href=\"https:\/\/doi.org\/10.1038\/ajg.2009.511\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19956142\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Am%20J%20Gastroenterol&amp;title=Anti-goblet%20cell%20antibodies%20for%20the%20diagnosis%20of%20autoimmune%20enteropathy?&amp;author=F%20Biagi&amp;author=PI%20Bianchi&amp;author=L%20Trotta&amp;volume=104&amp;publication_year=2009&amp;pages=3112&amp;pmid=19956142&amp;doi=10.1038\/ajg.2009.511&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>14.Elkon K, Casali P. Nature and functions of autoantibodies. Nat Clin Pract Rheumatol 2008;4:491-498. https:\/\/doi.org\/10.1038\/ncprheum0895 10.1038\/ncprheum0895\u00a0[<a href=\"https:\/\/doi.org\/10.1038\/ncprheum0895\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2703183\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18756274\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Nat%20Clin%20Pract%20Rheumatol&amp;title=Nature%20and%20functions%20of%20autoantibodies&amp;author=K%20Elkon&amp;author=P%20Casali&amp;volume=4&amp;publication_year=2008&amp;pages=491-498&amp;pmid=18756274&amp;doi=10.1038\/ncprheum0895&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>15.Patey-Mariaud de Serre N, Canioni D, Ganousse S, Rieux-Laucat F, Goulet O, Ruemmele F, Brousse N. Digestive histopathological presentation of IPEX syndrome. Mod Pathol 2009;22:95-102. https:\/\/doi.org\/10.1038\/modpathol.2008.161 10.1038\/modpathol.2008.161\u00a0[<a href=\"https:\/\/doi.org\/10.1038\/modpathol.2008.161\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18820676\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Mod%20Pathol&amp;title=Digestive%20histopathological%20presentation%20of%20IPEX%20syndrome&amp;author=N%20Patey-Mariaud%20de%20Serre&amp;author=D%20Canioni&amp;author=S%20Ganousse&amp;author=F%20Rieux-Laucat&amp;author=O%20Goulet&amp;volume=22&amp;publication_year=2009&amp;pages=95-102&amp;pmid=18820676&amp;doi=10.1038\/modpathol.2008.161&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>16.Zhang X, Olsen N, Zheng SG. The progress and prospect of regulatory T cells in autoimmune diseases. J Autoimmun 2020;111:102461. https:\/\/doi.org\/10.1016\/j.jaut.2020.102461 10.1016\/j.jaut.2020.102461\u00a0[<a href=\"https:\/\/doi.org\/10.1016\/j.jaut.2020.102461\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32305296\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J%20Autoimmun&amp;title=The%20progress%20and%20prospect%20of%20regulatory%20T%20cells%20in%20autoimmune%20diseases&amp;author=X%20Zhang&amp;author=N%20Olsen&amp;author=SG%20Zheng&amp;volume=111&amp;publication_year=2020&amp;pages=102461&amp;pmid=32305296&amp;doi=10.1016\/j.jaut.2020.102461&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>17.Otsubo K, Kanegane H, Kamachi Y, et al. Identification of FOXP3-negative regulatory T-like (CD4(+) CD25(+) CD127(low)) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Clin Immunol 2011;141:111-120. https:\/\/doi.org\/10.1016\/j.clim.2011.06.006 10.1016\/j.clim.2011.06.006\u00a0[<a href=\"https:\/\/doi.org\/10.1016\/j.clim.2011.06.006\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21802372\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Clin%20Immunol&amp;title=Identification%20of%20FOXP3-negative%20regulatory%20T-like%20(CD4(+)%20CD25(+)%20CD127(low))%20cells%20in%20patients%20with%20immune%20dysregulation,%20polyendocrinopathy,%20enteropathy,%20X-linked%20syndrome&amp;author=K%20Otsubo&amp;author=H%20Kanegane&amp;author=Y%20Kamachi&amp;volume=141&amp;publication_year=2011&amp;pages=111-120&amp;pmid=21802372&amp;doi=10.1016\/j.clim.2011.06.006&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>18.Gambineri E, Ciullini Mannurita S, et al. Clinical, immunological, and molecular heterogeneity of 173 patients with the phenotype of immune dysregulation, polyendocrinopathy, enteropathy, x-linked (IPEX) syndrome. Front Immunol 2018;9:2411. https:\/\/doi.org\/10.3389\/fimmu.2018.02411 10.3389\/fimmu.2018.02411\u00a0[<a href=\"https:\/\/doi.org\/10.3389\/fimmu.2018.02411\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6223101\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30443250\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front%20Immunol&amp;title=Clinical,%20immunological,%20and%20molecular%20heterogeneity%20of%20173%20patients%20with%20the%20phenotype%20of%20immune%20dysregulation,%20polyendocrinopathy,%20enteropathy,%20x-linked%20(IPEX)%20syndrome&amp;author=E%20Gambineri&amp;author=Mannurita%20S%20Ciullini&amp;volume=9&amp;publication_year=2018&amp;pages=2411&amp;pmid=30443250&amp;doi=10.3389\/fimmu.2018.02411&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>19.Van Gool F, Nguyen MLT, Mumbach MR, et al. A mutation in the transcription factor Foxp3 drives T helper 2 effector function in regulatory T cells. Immunity 2019;50:362-377. e6. https:\/\/doi.org\/10.1016\/j.immuni.2018.12.016 10.1016\/j.immuni.2018.12.016\u00a0[<a href=\"https:\/\/doi.org\/10.1016\/j.immuni.2018.12.016\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6476426\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30709738\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Immunity&amp;title=A%20mutation%20in%20the%20transcription%20factor%20Foxp3%20drives%20T%20helper%202%20effector%20function%20in%20regulatory%20T%20cells&amp;author=F%20Van%20Gool&amp;author=MLT%20Nguyen&amp;author=MR%20Mumbach&amp;volume=50&amp;publication_year=2019&amp;pages=362-377.%20e6&amp;pmid=30709738&amp;doi=10.1016\/j.immuni.2018.12.016&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>20.Kinnunen T, Chamberlain N, Morbach H, et al. Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells. Blood 2013;121:1595-1603. https:\/\/doi.org\/10.1182\/blood-2012-09-457465 10.1182\/blood-2012-09-457465\u00a0[<a href=\"https:\/\/doi.org\/10.1182\/blood-2012-09-457465\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3587322\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23223361\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Blood&amp;title=Accumulation%20of%20peripheral%20autoreactive%20B%20cells%20in%20the%20absence%20of%20functional%20human%20regulatory%20T%20cells&amp;author=T%20Kinnunen&amp;author=N%20Chamberlain&amp;author=H%20Morbach&amp;volume=121&amp;publication_year=2013&amp;pages=1595-1603&amp;pmid=23223361&amp;doi=10.1182\/blood-2012-09-457465&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>21.Perheentupa J. APS-I\/APECED: the clinical disease and therapy. Endocrinol Metab Clin North Am 2002;31:295-320, vi. https:\/\/doi.org\/10.1016\/s0889-8529(01)000135 10.1016\/s0889-8529(01)000135\u00a0[<a href=\"https:\/\/doi.org\/10.1016\/s0889-8529(01)000135\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12092452\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Endocrinol%20Metab%20Clin%20North%20Am&amp;title=APS-I\/APECED:%20the%20clinical%20disease%20and%20therapy&amp;author=J%20Perheentupa&amp;volume=31&amp;publication_year=2002&amp;pages=295-320&amp;pmid=12092452&amp;doi=10.1016\/s0889-8529(01)000135&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>22.Kisand K, Peterson P. Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy: known and novel aspects of the syndrome: APECED: known and novel aspects of the syndrome. Ann NY Acad Sci 2011;1246:77-91. https:\/\/doi.org\/10.1111\/j.1749-6632.2011.06308.x 10.1111\/j.1749-6632.2011.06308.x\u00a0[<a href=\"https:\/\/doi.org\/10.1111\/j.1749-6632.2011.06308.x\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22236432\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Ann%20NY%20Acad%20Sci&amp;title=Autoimmune%20polyendocrinopathy%20candidiasis%20ectodermal%20dystrophy:%20known%20and%20novel%20aspects%20of%20the%20syndrome:%20APECED:%20known%20and%20novel%20aspects%20of%20the%20syndrome&amp;author=K%20Kisand&amp;author=P%20Peterson&amp;volume=1246&amp;publication_year=2011&amp;pages=77-91&amp;pmid=22236432&amp;doi=10.1111\/j.1749-6632.2011.06308.x&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>23.Yang S, Fujikad N, Kolodin D, et al. Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance. Science 2015;348:589-594. https:\/\/doi.org\/10.1126\/science.aaa7017 10.1126\/science.aaa7017\u00a0[<a href=\"https:\/\/doi.org\/10.1126\/science.aaa7017\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4710357\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25791085\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Science&amp;title=Immune%20tolerance.%20Regulatory%20T%20cells%20generated%20early%20in%20life%20play%20a%20distinct%20role%20in%20maintaining%20self-tolerance&amp;author=S%20Yang&amp;author=N%20Fujikad&amp;author=D%20Kolodin&amp;volume=348&amp;publication_year=2015&amp;pages=589-594&amp;pmid=25791085&amp;doi=10.1126\/science.aaa7017&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>24.Singhi AD, Goyal A, Davison JM, et al. Pediatric autoimmune enteropathy: an entity frequently associated with immunodeficiency disorders. Mod Pathol 2014;27:543-553. https:\/\/doi.org\/10.1038\/modpathol.2013.150 10.1038\/modpathol.2013.150\u00a0[<a href=\"https:\/\/doi.org\/10.1038\/modpathol.2013.150\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24051695\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Mod%20Pathol&amp;title=Pediatric%20autoimmune%20enteropathy:%20an%20entity%20frequently%20associated%20with%20immunodeficiency%20disorders&amp;author=AD%20Singhi&amp;author=A%20Goyal&amp;author=JM%20Davison&amp;volume=27&amp;publication_year=2014&amp;pages=543-553&amp;pmid=24051695&amp;doi=10.1038\/modpathol.2013.150&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>25.Wosen JE, Mukhopadhyay D, Macaubas C, et al. Epithelial MHC class II expression and its role in antigen presentation in the gastrointestinal and respiratory tracts. Front Immunol 2018;9:2144. https:\/\/doi.org\/10.3389\/fimmu.2018.02144 10.3389\/fimmu.2018.02144\u00a0[<a href=\"https:\/\/doi.org\/10.3389\/fimmu.2018.02144\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6167424\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30319613\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front%20Immunol&amp;title=Epithelial%20MHC%20class%20II%20expression%20and%20its%20role%20in%20antigen%20presentation%20in%20the%20gastrointestinal%20and%20respiratory%20tracts&amp;author=JE%20Wosen&amp;author=D%20Mukhopadhyay&amp;author=C%20Macaubas&amp;volume=9&amp;publication_year=2018&amp;pages=2144&amp;pmid=30319613&amp;doi=10.3389\/fimmu.2018.02144&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>26.Sanderson IR, Phillips AS, Spencer J, et al. Response to autoimmune enteropathy to cyclosporin A therapy. Gut 1991;32:1421-1425. https:\/\/doi.org\/10.1136\/gut.32.11.1421 10.1136\/gut.32.11.1421\u00a0[<a href=\"https:\/\/doi.org\/10.1136\/gut.32.11.1421\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1379182\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1752480\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Gut&amp;title=Response%20to%20autoimmune%20enteropathy%20to%20cyclosporin%20A%20therapy&amp;author=IR%20Sanderson&amp;author=AS%20Phillips&amp;author=J%20Spencer&amp;volume=32&amp;publication_year=1991&amp;pages=1421-1425&amp;pmid=1752480&amp;doi=10.1136\/gut.32.11.1421&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>27.Kobayashi I, Imamura K, Yamada M, et al. A 75-kD autoantigen recognized by sera from patients with X-linked autoimmune enteropathy associated with nephropathy. Clin Exp Immunol 1998;111:527-531. https:\/\/doi.org\/10.1046\/j.1365-2249.1998.00523.x 10.1046\/j.1365-2249.1998.00523.x\u00a0[<a href=\"https:\/\/doi.org\/10.1046\/j.1365-2249.1998.00523.x\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1904877\/\" target=\"_blank\" rel=\"noopener\">PMC free article<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9528893\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Clin%20Exp%20Immunol&amp;title=A%2075-kD%20autoantigen%20recognized%20by%20sera%20from%20patients%20with%20X-linked%20autoimmune%20enteropathy%20associated%20with%20nephropathy&amp;author=I%20Kobayashi&amp;author=K%20Imamura&amp;author=M%20Yamada&amp;volume=111&amp;publication_year=1998&amp;pages=527-531&amp;pmid=9528893&amp;doi=10.1046\/j.1365-2249.1998.00523.x&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n\n\n\n<p>28.Savage MO, Mirakian R, Wozniak ER, et al. Specific autoantibodies to gut epithelium in two infants with severe protracted diarrhoea. J Pediatr Gastroenterol Nutr 1985;4:187-195. https:\/\/doi.org\/10.1097\/00005176-198504000-00006 10.1097\/00005176-198504000-00006\u00a0[<a href=\"https:\/\/doi.org\/10.1097\/00005176-198504000-00006\" target=\"_blank\" rel=\"noreferrer noopener\">DOI<\/a>] [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/3886868\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>] [<a href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J%20Pediatr%20Gastroenterol%20Nutr&amp;title=Specific%20autoantibodies%20to%20gut%20epithelium%20in%20two%20infants%20with%20severe%20protracted%20diarrhoea&amp;author=MO%20Savage&amp;author=R%20Mirakian&amp;author=ER%20Wozniak&amp;volume=4&amp;publication_year=1985&amp;pages=187-195&amp;pmid=3886868&amp;doi=10.1097\/00005176-198504000-00006&amp;\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a>]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pediatric Autoimmune Disorders: Treating with Ayurveda Autoimmune disorders, conditions where the immune system mistakenly attacks healthy cells, are on the rise in children, affecting their physical and emotional well-being. Conditions like juvenile arthritis, pediatric Crohn&#8217;s disease, and Type 1 diabetes present unique challenges in pediatric care. Ayurveda offers a gentle, natural approach to treating pediatric [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4985,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"tdm_status":"","tdm_grid_status":"","footnotes":""},"categories":[80],"tags":[],"class_list":{"0":"post-3521","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-general"},"_links":{"self":[{"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/posts\/3521","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/comments?post=3521"}],"version-history":[{"count":2,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/posts\/3521\/revisions"}],"predecessor-version":[{"id":4986,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/posts\/3521\/revisions\/4986"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/media\/4985"}],"wp:attachment":[{"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/media?parent=3521"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/categories?post=3521"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eliteayurveda.com\/blog\/wp-json\/wp\/v2\/tags?post=3521"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}