Complications of Untreated Endometriosis: What You Need to Know
Table of Contents
Endometriosis is a chronic, often painful condition where tissue similar to the lining of the uterus (endometrium) grows outside the uterus, causing inflammation and scarring. While it can be managed through various treatments, leaving endometriosis untreated can lead to several serious complications that affect physical health, fertility, and overall quality of life (Lad, 2002). This article will explore the potential complications of untreated endometriosis and highlight the importance of timely diagnosis and intervention.
1. Chronic Pelvic Pain
One of the most common symptoms of untreated endometriosis is chronic pelvic pain. Over time, the presence of endometrial-like tissue outside the uterus can lead to the formation of scar tissue (adhesions), which binds organs together and causes significant discomfort (Singhal & Patel, 2020). This pain can be cyclical, worsening during menstruation, or become continuous, significantly affecting daily activities and mental well-being.
Impact of Chronic Pelvic Pain:
- Difficulty in performing routine tasks due to constant pain.
- Increased risk of depression and anxiety as a result of persistent discomfort.
- Dependency on pain medications, which can lead to long-term health issues (Sharma & Chandola, 2012).
2. Infertility
Untreated endometriosis is one of the leading causes of infertility. The condition can cause scarring and blockages in the fallopian tubes, preventing the egg and sperm from meeting. Endometrial tissue growing on the ovaries can also interfere with ovulation, making it difficult for women to conceive (Dash & Junius, 2012). It is estimated that 30-50% of women with endometriosis experience infertility (Bhavsar et al., 2020).
Impact of Infertility:
- Emotional distress from difficulties in conceiving.
- The need for invasive fertility treatments like in-vitro fertilization (IVF).
- Delayed or postponed family planning, which may lead to further complications related to age.
3. Formation of Endometriomas (Ovarian Cysts)
Endometriosis can lead to the formation of endometriomas, also known as “chocolate cysts.” These cysts are filled with old blood and can develop on the ovaries. Over time, they can grow larger, causing more pain and discomfort (Tiwari, 2017). Endometriomas may also affect ovarian function, further complicating fertility and menstrual cycles.
Risks of Endometriomas:
- Increased pain during menstruation, sexual activity, or ovulation.
- The potential rupture of cysts, which can cause severe abdominal pain and require emergency surgery.
- Permanent damage to the ovaries, affecting hormone regulation and fertility (Singhal & Patel, 2020).
4. Adhesions and Organ Dysfunction
One of the more serious complications of untreated endometriosis is the development of adhesions, which occur when scar tissue forms between organs and tissues that are not normally connected. These adhesions can result in organs becoming “glued” together, leading to restricted movement and function (Sharma & Chandola, 2012).
Impact of Adhesions:
- Disruption of normal organ function, particularly the bowels, bladder, and reproductive organs.
- Difficulty in urination and bowel movements due to adhesions forming on the bladder or intestines.
- The need for surgical intervention to remove adhesions, which can increase the risk of further complications.
5. Bowel and Bladder Issues
Endometriosis can spread to the intestines, bladder, or ureters, causing painful and debilitating gastrointestinal and urinary symptoms. Bowel endometriosis can lead to symptoms like constipation, diarrhea, or painful bowel movements, while bladder endometriosis may result in pain during urination and increased urgency (Bhavsar et al., 2020).
Complications in the Digestive and Urinary Systems:
- Bowel obstruction, a medical emergency where part of the intestines is blocked due to adhesions.
- Risk of kidney damage if endometrial tissue affects the ureters, which can obstruct the flow of urine from the kidneys to the bladder.
- Increased difficulty in managing both urinary and gastrointestinal symptoms simultaneously.
6. Increased Risk of Autoimmune and Inflammatory Disorders
Women with endometriosis are at a higher risk of developing autoimmune and inflammatory conditions. Research suggests that the chronic inflammation associated with endometriosis can trigger or exacerbate autoimmune diseases such as lupus, rheumatoid arthritis, and Hashimoto’s thyroiditis (Tiwari, 2017).
Related Health Risks:
- Increased inflammation in other parts of the body, leading to the development of conditions like fibromyalgia.
- More susceptibility to conditions linked to inflammation, such as cardiovascular disease (Dash & Junius, 2012).
7. Higher Risk of Certain Cancers
While rare, untreated endometriosis has been associated with an increased risk of developing certain types of cancers, particularly ovarian cancer and endometriosis-associated adenocarcinoma. Though the risk remains low, women with long-term untreated endometriosis should be aware of the potential for malignant transformation of endometriotic lesions (Sharma & Chandola, 2012).
Cancer Risk Factors:
- Endometrial-like tissue can undergo changes that make it more susceptible to developing into cancerous growths.
- The presence of endometriomas or chronic inflammation may elevate the risk of ovarian cancer over time (Lad, 2002).
8. Emotional and Mental Health Struggles
Living with untreated endometriosis can take a toll on emotional and mental health. Chronic pain, infertility, and the stress of dealing with a progressive disease can contribute to depression, anxiety, and a reduced quality of life. Women with endometriosis often experience feelings of frustration, helplessness, and isolation, particularly if their condition goes undiagnosed or untreated for long periods (Bhavsar et al., 2020).
Mental Health Impact:
- Increased risk of mood disorders like depression and anxiety due to the stress of managing chronic pain and other symptoms.
- A decrease in self-esteem and mental well-being due to body image issues, infertility, and the chronic nature of the disease.
- Strained relationships with partners, family members, and friends, as the condition affects sexual health and intimacy.
9. Quality of Life Decline
Ultimately, untreated endometriosis can have a profound impact on a woman’s overall quality of life. The pain, emotional distress, and physical limitations caused by the condition can interfere with personal relationships, career opportunities, and everyday activities (Lad, 2002).
Long-Term Effects:
- Decreased ability to work or attend social events due to chronic symptoms.
- Feelings of isolation and frustration as the condition progresses.
- Difficulty maintaining an active lifestyle, contributing to poor physical and mental health.
Conclusion
Endometriosis is a serious condition that requires timely diagnosis and treatment to prevent complications. From infertility and chronic pain to increased risks of autoimmune disorders and cancer, the potential consequences of untreated endometriosis can significantly affect a woman’s physical, emotional, and mental health. Ayurveda and other holistic approaches can play a role in managing the symptoms and addressing the root causes, but it is essential to consult healthcare professionals for comprehensive care (Singhal & Patel, 2020).
Understanding the complications of untreated endometriosis highlights the importance of early intervention and a proactive approach to managing this chronic condition. With proper treatment and support, women with endometriosis can lead healthier, more fulfilling lives.
References
1.Kvaskoff M, Mu F, Terry KL, Harris HR, Poole EM, Farland L, Missmer SA. Endometriosis: a high-risk population for major chronic diseases? Hum Reprod Update. 2015;21(4):500–16. Epub 2015/03/15. doi: 10.1093/humupd/dmv013. [DOI] [PMC free article] [PubMed] [Google Scholar]
2.**.Shafrir AL, Farland LV, Shah DK, Harris HR, Kvaskoff M, Zondervan K, Missmer SA. Risk for and consequences of endometriosis: A critical epidemiologic review. Best practice & research Clinical obstetrics & gynaecology. 2018;51:1–15. Epub 2018/07/19. doi: 10.1016/j.bpobgyn.2018.06.001. [DOI] [PubMed] [Google Scholar]; This article addresses the critical epidemiologic methodologic complexities in endometriosis research.
3.Kim JJ, Kurita T, Bulun SE. Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer. Endocrine reviews. 2013;34(1):130–62. Epub 2013/01/11. doi: 10.1210/er.2012-1043.. [DOI] [PMC free article] [PubMed] [Google Scholar]
4.Lebovic DI, Mueller MD, Taylor RN. Immunobiology of endometriosis. Fertil Steril. 2001;75(1):1–10. [DOI] [PubMed] [Google Scholar]
5.Podgaec S, Dias Junior JA, Chapron C, Oliveira RM, Baracat EC, Abrao MS. Th1 and Th2 ummune responses related to pelvic endometriosis. Revista da Associacao Medica Brasileira (1992). 2010;56(1):92–8. Epub 2010/03/27. [DOI] [PubMed] [Google Scholar]
6.Capobianco A, Rovere-Querini P. Endometriosis, a disease of the macrophage. Frontiers in immunology. 2013;4:9 Epub 2013/02/02. doi: 10.3389/fimmu.2013.00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
7.Nothnick WB. Treating endometriosis as an autoimmune disease. Fertil Steril. 2001;76(2):223–31. Epub 2001/07/31. [DOI] [PubMed] [Google Scholar]
8.Eisenberg VH, Zolti M, Soriano D. Is there an association between autoimmunity and endometriosis? Autoimmunity reviews. 2012;11(11):806–14. Epub 2012/02/15. doi: 10.1016/j.autrev.2012.01.005. [DOI] [PubMed] [Google Scholar]
9.Harris HR, Costenbader KH, Mu F, Kvaskoff M, Malspeis S, Karlson EW, Missmer SA. Endometriosis and the risks of systemic lupus erythematosus and rheumatoid arthritis in the Nurses’ Health Study II. Ann Rheum Dis. 2016;75(7):1279–84. Epub 2015/08/05. doi: 10.1136/annrheumdis-2015-207704. [DOI] [PMC free article] [PubMed] [Google Scholar]
10.Gandini S, Lazzeroni M, Peccatori FA, Bendinelli B, Saieva C, Palli D, Masala G, Caini S. The risk of extra-ovarian malignancies among women with endometriosis: A systematic literature review and meta-analysis. Crit Rev Oncol Hematol. 2019;134:72–81. Epub 2019/02/18. doi: 10.1016/j.critrevonc.2018.12.009. [DOI] [PubMed] [Google Scholar]
11.Institute NC. SEER cancer statistics review (CSR). 2017.
12.Research CotSotSiOC. Summary. Ovarian Cancers Evolving Paradigms in Research and Care. Washington, DC: The National Academies Press; 2016. [PubMed] [Google Scholar]
13.Pearce CL, Templeman C, Rossing MA, Lee A, Near AM, Webb PM, Nagle CM, Doherty JA, Cushing-Haugen KL, Wicklund KG, Chang-Claude J, Hein R, Lurie G, Wilkens LR, Carney ME, Goodman MT, Moysich K, Kjaer SK, Hogdall E, Jensen A, Goode EL, Fridley BL, Larson MC, Schildkraut JM, Palmieri RT, Cramer DW, Terry KL, Vitonis AF, Titus LJ, Ziogas A, Brewster W, Anton-Culver H, Gentry-Maharaj A, Ramus SJ, Anderson AR, Brueggmann D, Fasching PA, Gayther SA, Huntsman DG, Menon U, Ness RB, Pike MC, Risch H, Wu AH, Berchuck A. Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. Lancet Oncol. 2012;13(4):385–94. Epub 2012/03/01. doi: 10.1016/s1470-2045(11)70404-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
14.Wentzensen N, Poole EM, Trabert B, White E, Arslan AA, Patel AV, Setiawan VW, Visvanathan K, Weiderpass E, Adami HO, Black A, Bernstein L, Brinton LA, Buring J, Butler LM, Chamosa S, Clendenen TV, Dossus L, Fortner R, Gapstur SM, Gaudet MM, Gram IT, Hartge P, Hoffman-Bolton J, Idahl A, Jones M, Kaaks R, Kirsh V, Koh WP, Lacey JV Jr., Lee IM, Lundin E, Merritt MA, Onland-Moret NC, Peters U, Poynter JN, Rinaldi S, Robien K, Rohan T, Sandler DP, Schairer C, Schouten LJ, Sjoholm LK, Sieri S, Swerdlow A, Tjonneland A, Travis R, Trichopoulou A, van den Brandt PA, Wilkens L, Wolk A, Yang HP, Zeleniuch-Jacquotte A, Tworoger SS. Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium. J Clin Oncol. 2016;34(24):2888–98. Epub 2016/06/22. doi: 10.1200/jco.2016.66.8178. [DOI] [PMC free article] [PubMed] [Google Scholar]
15.Kurman RJ, Shih Ie M. The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded. The American journal of pathology. 2016;186(4):733–47. Epub 2016/03/26. doi: 10.1016/j.ajpath.2015.11.011. [DOI] [PMC free article] [PubMed] [Google Scholar]
16.Saavalainen L, Lassus H, But A, Tiitinen A, Harkki P, Gissler M, Pukkala E, Heikinheimo O. Risk of Gynecologic Cancer According to the Type of Endometriosis. Obstet Gynecol. 2018;131(6):1095–102. Epub 2018/05/10. doi: 10.1097/aog.0000000000002624 [DOI] [PubMed] [Google Scholar]
17.Anglesio MS, Papadopoulos N, Ayhan A, Nazeran TM, Noe M, Horlings HM, Lum A, Jones S, Senz J, Seckin T, Ho J, Wu RC, Lac V, Ogawa H, Tessier-Cloutier B, Alhassan R, Wang A, Wang Y, Cohen JD, Wong F, Hasanovic A, Orr N, Zhang M, Popoli M, McMahon W, Wood LD, Mattox A, Allaire C, Segars J, Williams C, Tomasetti C, Boyd N, Kinzler KW, Gilks CB, Diaz L, Wang TL, Vogelstein B, Yong PJ, Huntsman DG, Shih IM. Cancer-Associated Mutations in Endometriosis without Cancer. N Engl J Med. 2017;376(19):1835–48. Epub 2017/05/11. doi: 10.1056/NEJMoa1614814. [DOI] [PMC free article] [PubMed] [Google Scholar]
18.Chang WH, Wang KC, Lee WL, Huang N, Chou YJ, Feng RC, Yen MS, Huang BS, Guo CY, Wang PH. Endometriosis and the subsequent risk of epithelial ovarian cancer. Taiwan J Obstet Gynecol. 2014;53(4):530–5. Epub 2014/12/17. doi: 10.1016/j.tjog.2014.04.025. [DOI] [PubMed] [Google Scholar]
19.Haraguchi H, Koga K, Takamura M, Makabe T, Sue F, Miyashita M, Urata Y, Izumi G, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Oda K, Kawana K, Fujii T, Osuga Y. Development of ovarian cancer after excision of endometrioma. Fertil Steril. 2016;106(6):1432–7.e2. Epub 2016/08/21. doi: 10.1016/j.fertnstert.2016.07.1077. [DOI] [PubMed] [Google Scholar]
20.Melin AS, Lundholm C, Malki N, Swahn ML, Sparen P, Bergqvist A. Hormonal and surgical treatments for endometriosis and risk of epithelial ovarian cancer. Acta Obstet Gynecol Scand. 2013;92(5):546–54. Epub 2013/04/09. doi: 10.1111/aogs.12123. [DOI] [PubMed] [Google Scholar]
21.Bulun SE, Wan Y, Matei D. Epithelial Mutations in Endometriosis: Link to Ovarian Cancer. Endocrinology. 2019;160(3):626–38. Epub 2019/01/19. doi: 10.1210/en.2018-00794. [DOI] [PMC free article] [PubMed] [Google Scholar]
22.Herreros-Villanueva M, Chen CC, Tsai EM, Er TK. Endometriosis-associated ovarian cancer: What have we learned so far? Clin Chim Acta. 2019;493:63–72. Epub 2019/02/19. doi: 10.1016/j.cca.2019.02.016. [DOI] [PubMed] [Google Scholar]
23.Fathalla MF. Incessant ovulation–a factor in ovarian neoplasia? Lancet (London, England). 1971;2(7716):163 Epub 1971/07/17. doi: 10.1016/s0140-6736(71)92335-x. [DOI] [PubMed] [Google Scholar]