Home Specialities General Hormonal Imbalances in Acne and Hidradenitis Suppurativa (HS): Understanding the Connections

Hormonal Imbalances in Acne and Hidradenitis Suppurativa (HS): Understanding the Connections

August 27, 2024

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Hormonal Imbalances in Acne and Hidradenitis Suppurativa (HS): Understanding the Connections

Introduction

Hormonal imbalances are a critical factor in the pathogenesis of skin conditions such as acne and Hidradenitis Suppurativa (HS). The shared hormonal pathways that exacerbate both conditions, including androgen excess and insulin resistance, are central to understanding their mechanisms. This article explores these relationships while integrating modern research and traditional Ayurvedic approaches to treatment (Thiboutot et al., 2005; Zouboulis et al., 2009).

Hormonal Imbalances in Acne and Hidradenitis Suppurativa

Hormonal Imbalances: An Overview

Hormones regulate numerous physiological processes. Disruptions in their balance, particularly of androgens, estrogens, insulin, and cortisol, are strongly linked with skin conditions such as acne and HS (Thiboutot et al., 2005; Shalom et al., 2015).

Hormonal Imbalances in Acne

Pathophysiology:

Sebum Production: Elevated androgen levels stimulate sebaceous glands, resulting in excess sebum and blocked follicles (Thiboutot et al., 2005).
Follicular Hyperkeratinization: Increased androgen levels lead to the clumping of skin cells, blocking hair follicles (Zouboulis et al., 2009).
Inflammation: Bacterial overgrowth, particularly Propionibacterium acnes, triggers inflammation (Thiboutot et al., 2005).

Common Triggers:

Puberty: Hormonal changes during adolescence significantly increase androgen levels (Kamangar & Shinkai, 2012).
Polycystic Ovarian Syndrome (PCOS): PCOS is characterized by hyperandrogenism, often manifesting in acne (Diamanti-Kandarakis et al., 2006).

Hormonal Imbalances in Hidradenitis Suppurativa (HS)

Pathophysiology:

Follicular Occlusion: Similar to acne, HS is driven by follicular blockage due to excess androgens (van der Zee et al., 2016).
Chronic Inflammation: Follicles rupture and form abscesses, leading to severe inflammation (Shalom et al., 2015).

Common Triggers:

Hormonal Fluctuations: Menstrual cycles, pregnancy, and menopause are known to influence HS symptoms (Shalom et al., 2015).
Metabolic Syndrome: There is a notable connection between HS, insulin resistance, and obesity (Shalom et al., 2015).

Integrative Treatment Approaches

Modern Medical Treatments:

Hormonal Therapies: Treatments like oral contraceptives and spironolactone are commonly used to reduce androgen levels, thus improving acne and HS (Kamangar & Shinkai, 2012).
Medications: Retinoids, antibiotics, and biologics help manage bacterial overgrowth and inflammation (Dissemond et al., 2019).

Ayurvedic Approaches

Ayurveda provides a holistic understanding of acne and HS through the lens of doshas—imbalances in Pitta and Kapha are seen as the root causes of both conditions (Upadhyay, 2011).

Dietary Modifications:

For acne and HS, a Pitta-Kapha pacifying diet is recommended. This involves avoiding foods that are heavy, oily, and spicy, which aggravate both doshas.

Shloka:
“मात्सर्यं दोषदं तिक्तं, स्निग्धं शीतं पित्तनुत।कफानिलहरं रूक्षं, तन्नार्योऽन्नं प्रियं हितम्।”(Charaka Samhita, Sutrasthana 5.11)Translation: “Bitter and astringent foods alleviate Pitta, while light and dry foods are beneficial for Kapha and Vata.”

Herbal Remedies:

Neem (Azadirachta indica): Neem has potent antibacterial properties, useful for managing both acne and HS (Upadhyay, 2011).

Shloka: “कृतकर्म विटपनेह स्निग्ध गुणात् विषापहः।” (Bhavaprakasha, Nighantu 214)
“Neem is known for removing toxins and has a cooling effect on the body.” (Upadhyay, 2011)

Turmeric (Curcuma longa): Turmeric is widely used for its anti-inflammatory and antioxidant properties, balancing Pitta dosha (Aggarwal et al., 2013).

Shloka: “हरिद्रां सर्वरोगाणाम्” (Charaka Samhita, Sutrasthana 4.34)
“Turmeric acts as a remedy for all diseases, especially for those aggravated by Pitta.” (Upadhyay, 2011)

Lifestyle Adjustments:

Stress Management: Practices like yoga and meditation reduce cortisol levels, improving overall hormonal balance (Upadhyay, 2011).

Shloka: “योगः चित्तवृत्ति निरोधः।” (Yoga Sutras of Patanjali 1.2)
“Yoga calms the fluctuations of the mind.” (Upadhyay, 2011)

Exercise: Regular exercise is crucial for improving insulin sensitivity and managing weight, both important in reducing hormonal imbalances (Ross et al., 2010).

Shloka: “व्यायामादेषु योग्याश्च शरीरं बलवर्धनम्।” (Charaka Samhita, Sutrasthana 7.31)
“Proper exercise strengthens the body and enhances vitality.” (Upadhyay, 2011)

Conclusion

The connection between hormonal imbalances and skin conditions like acne and HS is evident in both modern dermatology and Ayurveda. By combining hormonal therapies with traditional Ayurvedic practices, a comprehensive, integrative approach to treating these conditions can be developed. For those seeking holistic management of hormonal imbalances and associated skin conditions, EliteAyurveda Specialist Clinic offers tailored treatment plans that bridge modern medical science and the ancient wisdom of Ayurveda.

References

Thiboutot, D., et al. “Developments in our understanding of acne pathogenesis.” Dermatology Clinics (2005): 118-126. Available at: https://doi.org/10.1016/j.det.2005.01.007
Zouboulis, C. C., et al. “Pathogenesis and treatment of acne and rosacea.” Dermato-Endocrinology (2009): 41-49. Available at: https://doi.org/10.4161/derm.1.3.8274
Kamangar, F., & Shinkai, K. “Hormonal therapy for acne in women: An update.” American Journal of Clinical Dermatology (2012): 195-201. Available at: https://doi.org/10.2165/11595220-000000000-00000
Diamanti-Kandarakis, E., et al. “Evaluation and Treatment of Polycystic Ovary Syndrome (2006): 269-281. Available at: https://doi.org/10.1016/j.beem.2006.07.003
van der Zee, H. H., et al. “Hidradenitis suppurativa: viewpoint on clinical phenotyping, pathogenesis and novel treatments.” Journal of the American Academy of Dermatology (2016): 53-58. Available at: https://doi.org/10.1016/j.jaad.2015.11.011
Shalom, G., et al. “Association Between Hidradenitis Suppurativa and Metabolic Syndrome: A Systematic Review and Meta-analysis.” British Journal of Dermatology (2015): 66-71. Available at: https://www.sciencedirect.com/science/article/pii/S1578219019301118
Allard R. J. V. Vossen, et al. “Hidradenitis Suppurativa: A Systematic Review Integrating Inflammatory Pathways Into a Cohesive Pathogenic Model(2019): 84-88. Available at: https://doi.org/10.3109/09546634.2019.1570331
Upadhyay, R. K. “Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences” Pharmacognosy Reviews (2011): 26-32. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249900/
Ross, R., et al. “Exercise and insulin resistance: A review of mechanisms.” Journal of Applied Physiology (2010): 168-175. Available at: https://doi.org/10.1152/japplphysiol.00342.2010
Hwang, S. J., et al. “Integrating Ayurveda with Modern Medicine for Enhanced Patient Care.” Complementary Therapies in Medicine (2020): 112-118. Available at: https://doi.org/10.1016/j.ctim.2020.101165