Non-Invasive Biomarkers for Hidradenitis Suppurativa

March 8, 2025

Non-Invasive Biomarkers for Hidradenitis Suppurativa (HS) & Ayurvedic Insights

Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disorder that significantly affects the quality of life. Early and accurate diagnosis is crucial, yet traditional diagnostic methods often rely on clinical assessment, biopsies, and invasive procedures. Non-invasive biomarkers are emerging as powerful tools to aid in early detection, monitoring disease progression, and evaluating treatment response.

From an Ayurvedic perspective, HS is linked to Pitta-Kapha imbalance, ama (toxins) accumulation, and impaired Agni (digestive fire). At EliteAyurveda, under the guidance of Dr. Adil Moulanchikkal, we focus on identifying early indicators of disease progression through a holistic approach.

Non-Invasive Biomarkers for Hidradenitis Suppurativa

📖 The Role of Non-Invasive Biomarkers in HS Diagnosis

Biomarkers are biological indicators that help detect and monitor diseases. Non-invasive biomarkers can be identified through blood, saliva, urine, and skin swabs, making them more accessible and convenient than invasive procedures.

🔬 Key Non-Invasive Biomarkers for HS

1️⃣ Inflammatory Biomarkers

Chronic inflammation is the hallmark of HS. Identifying inflammatory markers can help assess disease severity and treatment response.

✔️ C-Reactive Protein (CRP) – Elevated levels indicate systemic inflammation.
✔️ Erythrocyte Sedimentation Rate (ESR) – Measures overall inflammatory activity.
✔️ Proinflammatory Cytokines (IL-1β, IL-6, TNF-α) – Markers of active HS flares.
✔️ S100 Proteins (S100A8, S100A9) – Correlate with HS severity and progression.

2️⃣ Microbiome & Skin Biomarkers

HS is associated with dysbiosis (imbalance of skin and gut bacteria). Identifying microbial biomarkers can help in personalized treatment approaches.

✔️ Cutibacterium acnes & Staphylococcus aureus Overgrowth – Linked to infected HS lesions.
✔️ Skin Dysbiosis Score (SDS) – Measures bacterial imbalances on HS-prone skin.
✔️ Fecal Calprotectin (Gut Inflammation Marker) – Indicates gut-skin axis involvement in HS.

3️⃣ Hormonal & Metabolic Biomarkers

HS is often associated with metabolic disorders like insulin resistance, obesity, and PCOS. Monitoring metabolic markers can help in early interventions.

✔️ Insulin & HOMA-IR (Insulin Resistance Index) – Common in HS patients with metabolic syndrome.
✔️ Testosterone & Androgens – Elevated levels contribute to HS development in PCOS cases.
✔️ Leptin & Adiponectin (Fat Tissue Hormones) – Indicate metabolic inflammation linked to HS.

4️⃣ Skin Barrier & Oxidative Stress Biomarkers

HS lesions indicate barrier dysfunction and oxidative stress, which can be assessed non-invasively.

✔️ Filaggrin & Skin Barrier Proteins – Reduced levels indicate impaired skin defense.
✔️ Malondialdehyde (MDA) & Reactive Oxygen Species (ROS) – Indicate oxidative damage in HS lesions.
✔️ Sebum Composition Analysis – Determines oil imbalance contributing to HS.

🌿 Ayurvedic Perspective on HS & Biomarkers

In Ayurveda, HS is considered a Pitta-Kapha disorder, influenced by ama (toxins), low Agni (digestive fire), and blocked Srotas (body channels).

🔍 Ayurvedic Diagnostic Markers for HS

✔️ Nadi Pariksha (Pulse Diagnosis) – Detects inflammatory imbalances at an early stage.
✔️ Jihva Pariksha (Tongue Examination) – Thick coating suggests toxin accumulation (Ama).
✔️ Mutra & Mala Pariksha (Urine & Stool Analysis) – Identifies gut-related imbalances affecting HS.
✔️ Twak Pariksha (Skin Assessment) – Determines dosha imbalances through skin texture, color, and moisture.

🌿 Ayurvedic Herbal Medications for HS

At EliteAyurveda, we create personalized herbal formulations to target the root causes of HS and promote natural healing.

🌱 Anti-Inflammatory Blend – Reduces cytokine activity and prevents HS flare-ups.
🌱 Gut Restoration Formula – Strengthens digestion and improves gut-skin connection.
🌱 Metabolic Balance Capsules – Supports insulin function and reduces metabolic inflammation.
🌱 Skin Repair Tonic – Enhances skin healing and prevents scarring.
🌱 Hormonal Regulation Formula – Balances endocrine function and reduces androgen dominance.

🔹 These formulations are customized and gradually adjusted as the body begins to restore balance naturally.

🔄 How Ayurveda Reverses HS Naturally

✅ 1. Deep Detoxification (Shodhana Therapy)
✔️ Removes inflammatory toxins from the body.
✔️ Restores liver function for better metabolism.

✅ 2. Regulating Gut Health & Digestion
✔️ Balances gut microbiome and reduces inflammatory triggers.
✔️ Strengthens Agni (digestive fire) for better nutrient absorption.

✅ 3. Correcting Hormonal Imbalances
✔️ Supports adrenal, ovarian, and thyroid health.
✔️ Reduces insulin resistance linked to HS.

✅ 4. Strengthening Skin Immunity
✔️ Prevents recurrent infections and promotes faster healing.
✔️ Supports healthy skin barrier function.

📖 Real Patient Success Story

“For years, I struggled with painful HS flare-ups, relying on antibiotics and steroids for relief. After switching to an Ayurvedic approach focused on gut healing, detoxification, and metabolic balance, my symptoms significantly reduced. Today, I have fewer flare-ups and improved skin health.”
— Riya M., Hyderabad

👨‍⚕️ From the Doctor’s Desk: Dr. Adil Moulanchikkal

“HS is not just a skin disease; it’s a systemic inflammatory condition influenced by metabolism, gut health, and hormonal imbalances. While non-invasive biomarkers help in early detection, Ayurveda focuses on reversing the root causes. At EliteAyurveda, we integrate modern diagnostic tools with personalized Ayurvedic treatments to offer a sustainable, natural solution.”