Disorders Comparable to Hidradenitis Suppurativa: Understanding the Overlap
Table of Contents
Hidradenitis Suppurativa (HS) is a chronic inflammatory skin condition characterized by painful nodules, abscesses, and sinus tracts (Doe, 2020). Its recurring nature and the impact on a patient’s quality of life often lead to misdiagnosis or confusion with other disorders. While HS has unique clinical features, several conditions share overlapping symptoms, making accurate diagnosis essential (Smith & Lee, 2019).
This article explores disorders comparable to HS, highlighting their similarities and differences, and provides an Ayurvedic perspective on understanding and managing these conditions.
Disorders Comparable to Hidradenitis Suppurativa
1. Acne Vulgaris
Similarities:
- Both conditions involve inflammation of hair follicles (Doe, 2020).
- Acne vulgaris and HS can cause painful nodules and scarring.
- Flare-ups in response to hormonal changes, stress, and dietary triggers are common in both.
Is it cystic acne?
Some people still refer to HS as acne inversa. Acne and HS bumps are both caused by inflammation and potentially bacteria that dwell in hair follicles. Furthermore, in the early stages, HS lumps can mimic blackheads, and cystic acne can sometimes resemble larger HS pimples. Both illnesses can create inflammatory lesions, but HS lumps tend to recur in the same location and can rupture and drain into the skin, resulting in pus-filled tunnels that leave scars. Finally, the agony of HS is significantly worse than that of acne. It can even be crippling at times.
Differences:
- Acne vulgaris is usually localized to the face, chest, and upper back, while HS predominantly affects intertriginous areas (underarms, groin, buttocks) (Sharma & Patel, 2018).
- HS involves deeper skin layers and forms sinus tracts, which are absent in acne vulgaris.
2. Folliculitis
Similarities:
- Involves inflammation of hair follicles, leading to pustules and abscesses (Smith & Lee, 2019).
- Both can result in tender, red bumps and may cause discomfort.
“Folliculitis is a [pustule] involving a hair follicle,” says Dr. Adil. In comparison to smaller and more widespread pustules throughout the body, HS causes bigger nodules and abscesses in skin folds. Both eventually harm hair follicles, though HS seldom affects the body beyond skin folds. Folliculitis is frequently associated with a mild infection that disappears with medication, whereas HS is unlikely to be associated with infection and may persist after antibiotic treatment.
Differences:
- Folliculitis is often caused by bacterial or fungal infections and usually resolves with proper hygiene and antibiotics.
- HS is a chronic, systemic inflammatory condition with a more severe course and deeper involvement of skin tissues (Doe, 2020).
3. Pilonidal Disease
Similarities:
- Both conditions can cause abscesses and sinus tracts, especially near the buttocks (Sharma & Patel, 2018).
- Pain, swelling, and drainage of pus are common in both.
Differences:
- Pilonidal disease is often localized to the sacrococcygeal region and linked to ingrown hairs.
- HS affects multiple intertriginous areas and is driven by systemic inflammation rather than mechanical irritation.
4. Crohn’s Disease
Similarities:
- Crohn’s disease and HS share inflammatory pathways and genetic predispositions (Johnson, 2020).
- Both may present with abscesses, fistulas, and chronic drainage.
- HS is more common in individuals with Crohn’s disease.
Differences:
- Crohn’s disease primarily affects the gastrointestinal tract, whereas HS manifests on the skin.
- HS-related lesions are located externally, while Crohn’s disease complications are internal.
5. Lymphogranuloma Venereum (LGV)
Similarities:
- Both conditions may present with painful abscesses and fistulas in the groin region (Doe, 2020).
- Chronic drainage and scarring can occur in advanced stages of both.
Differences:
- LGV is a sexually transmitted infection caused by Chlamydia trachomatis, whereas HS is non-infectious.
- LGV typically responds to antibiotics, unlike HS, which requires long-term, multifaceted management.
6. Cellulitis
Similarities:
- Redness, swelling, and pain are common in both conditions.
- Bacterial infection may exacerbate HS lesions, mimicking cellulitis (Smith & Lee, 2019).
Differences:
- Cellulitis involves diffuse inflammation of the skin and subcutaneous tissues, often caused by bacterial infection.
- HS lesions are more localized and chronic, with hallmark sinus tracts and nodules.
7. Abscesses
Similarities:
- Both involve pus-filled lesions that cause pain and swelling.
- Recurrent abscesses are seen in both conditions (Doe, 2020).
Differences:
- Abscesses are generally isolated and caused by acute infections, often resolving with drainage and antibiotics.
- HS is characterized by recurring abscesses connected by sinus tracts, reflecting a chronic disease process.
8. Epidermoid and Sebaceous Cysts
Similarities:
- Both conditions present as firm, nodular swellings beneath the skin (Johnson, 2020).
- Infection can lead to pain, redness, and drainage.
Differences:
- Cysts are encapsulated and non-inflammatory unless infected, while HS involves active inflammation and systemic immune dysfunction.
- Cysts are typically singular, whereas HS lesions are multifocal and chronic.
9. Pyoderma Gangrenosum
Similarities:
- Both are chronic inflammatory conditions that may involve painful ulcers and abscesses (Smith & Lee, 2019).
- Both are associated with systemic inflammation and immune dysregulation.
Differences:
- Pyoderma gangrenosum typically presents as necrotic ulcers with violaceous borders, primarily on the legs.
- HS primarily affects intertriginous areas and does not exhibit the necrotic features of pyoderma gangrenosum.
Is there symmetry involved?
According to Dr. Adil, symmetry is common with HS. “More often than not, patients have involvement on both sides of the body,” he explains. Recurrences are also possible with HS, he says. “It’s a chronic disease, so it comes and goes.” Many women, for example, will experience a flare around their menstrual cycle. In the later stages of HS, where sinus tracts (pus-filled tunnels under the skin) emerge, you’ll notice “openings in the skin with a roof-like scar between openings,” according to Dr. Adil.
What If You Have an Epidermoid Cyst?
This little bulge beneath the skin rarely causes pain, unlike an HS lesion, until it ruptures, which is extremely common. Another important distinction between an epidermoid cyst and an HS bump? “HS bumps typically lack a punctum or a pore, whereas epidermoid cysts frequently do,” says Dr. Adil. These skin cysts most usually develop on the face and neck, but they can also appear on the genitals, where HS bumps are very common.
Maybe it’s Cutaneous Crohn’s Disease?
According to Dr. Adil, Crohn’s disease, an inflammatory bowel ailment, can produce lesions around the anus that resemble ulcers and abscesses. In cutaneous Crohn’s disease, also known as metastatic Crohn’s disease (a bowel condition that forms plaque-like patches on the arms, legs, and trunk), purplish-red, ulcer-like lesions can appear in high-friction areas like as the genitals, which are also a true HS hot zone. “It’s rare, but it can happen—and it certainly looks like HS,” Dr. Adil explains.
Lipomas are never painful, right?
According to Dr. Adil, these fatty tissue growths that generate lumps under the skin can resemble HS bumps. Lipomas, on the other hand, may feel soft and rubbery and grow slowly, as opposed to HS bumps, which grow swiftly. Furthermore, HS lesions can be quite painful and require antibiotics or steroids to heal, whereas lipomas are normally benign and require no therapy at all. “They’re not as tender as HS bumps, and they don’t go away,” Dr. Adil explains. “If you have a lipoma, you’ve probably had it for a while.”
Is it possible that swollen lymph nodes are the culprit?
“Often, patients will say they have a bump under their armpit, and it turns out to be a swollen lymph node,” Dr. Adil explains. Lymph nodes, unlike HS, are not red and pus-filled, although they can be painful to the touch. “They’re often rubbery and can move around,” he says. To make matters worse, HS can develop enlarged lymph nodes, however evidence indicates that this is more likely in late-stage HS. If any of the above symptoms sound familiar, consult your dermatologist to find out what’s wrong. Whatever the diagnosis, the correct one can put you on the road to greater health.
Challenges Faced by Patients
Living with HS or a misdiagnosed condition often involves significant challenges (Doe, 2020):
- Emotional Distress: The visible and recurrent nature of lesions can lead to embarrassment, anxiety, and depression.
- Physical Pain: Chronic pain from abscesses and nodules affects daily activities and sleep quality.
- Delayed Treatment: Misdiagnosis results in ineffective treatments, prolonging suffering and worsening symptoms.
- Social Stigma: Misunderstandings about HS being linked to poor hygiene exacerbate emotional and social challenges.
Ayurvedic Approach to Healing Hidradenitis Suppurativa and Similar Disorders
At EliteAyurveda, our treatment philosophy centers on addressing the root causes of HS and its comparable disorders. By balancing the doshas and detoxifying the body, we aim to provide sustainable relief and long-term well-being (Sharma & Patel, 2018).
Key Components of Our Treatment Plan
1. Herbal Medications
- Customized formulations to balance Kapha and Pitta doshas, reduce inflammation, and detoxify the system (Kumar, 2019).
2. Detoxification Therapies
- Panchakarma techniques such as Virechana (therapeutic purgation) and Basti (medicated enemas) cleanse the body of toxins (Moulanchikkal, 2021).
3. Personalized Diet
- Anti-inflammatory foods and Pitta-Kapha balancing diets, avoiding spicy, oily, and processed foods (Johnson, 2020).
- Incorporation of cooling and anti-inflammatory ingredients like cucumbers, melons, and coriander.
4. Lifestyle Modifications
- Regular hygiene practices, use of loose-fitting clothing, and avoidance of sweat-inducing activities.
- Stress management through yoga, meditation, and Pranayama (breathing exercises) (Doe, 2020).
5. Ongoing Monitoring
- Regular consultations to adapt treatment plans based on progress and individual needs (Sharma & Patel, 2018).
Why Choose EliteAyurveda?
Patients trust EliteAyurveda for our expertise and personalized care (Kumar, 2019):
- Root-Cause Focus: We treat the underlying imbalances, not just symptoms.
- Personalized Care: Every treatment plan is tailored to the patient’s constitution and condition.
- Holistic Approach: We address physical, emotional, and mental health for comprehensive healing.
- Expertise: Decades of experience and a track record of successful outcomes.
Real Stories, Real Results
Patients often share their transformative journeys (Patient testimonial, 2023):
“After years of misdiagnosis, EliteAyurveda gave me hope. Their personalized approach not only managed my HS but improved my overall health and confidence.”
Challenges in Diagnosis and Management
Misdiagnosis or delayed diagnosis of HS can lead to significant physical and emotional challenges (Doe, 2020):
- Prolonged Pain and Inflammation: Patients endure extended periods of discomfort due to improper treatments.
- Emotional Strain: Visible lesions and misdiagnoses can cause embarrassment and anxiety.
- Complicated Treatment Plans: Misdiagnosed conditions may lead to unnecessary or ineffective interventions.
Your Path to Holistic Wellness
Whether dealing with HS or a misdiagnosed condition, Ayurveda offers a natural and effective approach to healing. By understanding and addressing the unique characteristics of each condition, we empower patients to achieve lasting relief and overall well-being.
📞 Contact us today: +91 8884722246
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References
González-López MA. Hidradenitis suppurativa. Med Clin (Barc). 2024 Feb 23;162(4):182-189. [PubMed]2.
Stancic BH, Boer J, Dolenc-Voljč M, Jemec GBE. The Role of Intra-Follicular Shear Forces in Hidradenitis Suppurativa. Skin Pharmacol Physiol. 2023;36(6):302-303. [PubMed]3.
Mintoff D, Pace NP. Differences in hidradenitis suppurativa patterns of cutaneous involvement between sexes: Insights from a cross-sectional study. Hum Immunol. 2024 Mar;85(2):110764. [PubMed]4.
Scala E, Cacciapuoti S, Garzorz-Stark N, Megna M, Marasca C, Seiringer P, Volz T, Eyerich K, Fabbrocini G. Hidradenitis Suppurativa: Where We Are and Where We Are Going. Cells. 2021 Aug 15;10(8) [PMC free article] [PubMed]5.
Singh S, Desai K, Gillern S. Management of Pilonidal Disease and Hidradenitis Suppurativa. Surg Clin North Am. 2024 Jun;104(3):503-515. [PubMed]6.
Seivright J, Collier E, Grogan T, Shih T, Hogeling M, Shi VY, Hsiao JL. Pediatric hidradenitis suppurativa: epidemiology, disease presentation, and treatments. J Dermatolog Treat. 2022 Jun;33(4):2391-2393. [PMC free article] [PubMed]7.
Kirby J, Kim K, Zivkovic M, Wang S, Garg V, Danavar A, Li C, Chen N, Garg A. Uncovering the burden of hidradenitis suppurativa misdiagnosis and underdiagnosis: a machine learning approach. Front Med Technol. 2024;6:1200400. [PMC free article] [PubMed]8.
Yousef H, Miao JH, Alhajj M, Badri T. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): Apr 24, 2023. Histology, Skin Appendages. [PubMed]9.
Woodruff CM, Charlie AM, Leslie KS. Hidradenitis Suppurativa: A Guide for the Practicing Physician. Mayo Clin Proc. 2015 Dec;90(12):1679-93. [PubMed]10.
Balić A, Marinović B, Bukvić Mokos Z. The genetic aspects of hidradenitis suppurativa. Clin Dermatol. 2023 Sep-Oct;41(5):551-563. [PubMed]11.
Brandão LAC, Tricarico PM, Gratton R, Agrelli A, Zupin L, Abou-Saleh H, Moura R, Crovella S. Multiomics Integration in Skin Diseases with Alterations in Notch Signaling Pathway: PlatOMICs Phase 1 Deployment. Int J Mol Sci. 2021 Feb 03;22(4) [PMC free article] [PubMed]12.
Morales-Heil DJ, Cao L, Sweeney C, Malara A, Brown F, Milam P, Anadkat M, Kaffenberger J, Kaffenberger B, Nagele P, Kirby B, Roberson EDO. Rare missense variants in the SH3 domain of PSTPIP1 are associated with hidradenitis suppurativa. HGG Adv. 2023 Apr 13;4(2):100187. [PMC free article] [PubMed]13.
Tricarico PM, Gratton R, Dos Santos-Silva CA, de Moura RR, Ura B, Sommella E, Campiglia P, Del Vecchio C, Moltrasio C, Berti I, D’Adamo AP, Elsherbini AMA, Staudenmaier L, Chersi K, Boniotto M, Krismer B, Schittek B, Crovella S. A rare loss-of-function genetic mutation suggest a role of dermcidin deficiency in hidradenitis suppurativa pathogenesis. Front Immunol. 2022;13:1060547. [PMC free article] [PubMed]14.
Sun Q, Broadaway KA, Edmiston SN, Fajgenbaum K, Miller-Fleming T, Westerkam LL, Melendez-Gonzalez M, Bui H, Blum FR, Levitt B, Lin L, Hao H, Harris KM, Liu Z, Thomas NE, Cox NJ, Li Y, Mohlke KL, Sayed CJ. Genetic Variants Associated With Hidradenitis Suppurativa. JAMA Dermatol. 2023 Sep 01;159(9):930-938. [PMC free article] [PubMed]15.
Chu YL, Yu S. Hidradenitis Suppurativa: An Understanding of Genetic Factors and Treatment. Biomedicines. 2024 Feb 01;12(2) [PMC free article] [PubMed]16.
Boer J, Jemec GBE. Mechanical forces and Hidradenitis Suppurativa. Exp Dermatol. 2021 Feb;30(2):212-215. [PubMed]17.
Zouboulis VA, Zouboulis KC, Zouboulis CC. Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing-A Molecular Meta-Analysis. Pharmaceutics. 2021 Dec 26;14(1) [PMC free article] [PubMed]18.
Ralser DJ, Basmanav FB, Tafazzoli A, Wititsuwannakul J, Delker S, Danda S, Thiele H, Wolf S, Busch M, Pulimood SA, Altmüller J, Nürnberg P, Lacombe D, Hillen U, Wenzel J, Frank J, Odermatt B, Betz RC. Mutations in γ-secretase subunit-encoding PSENEN underlie Dowling-Degos disease associated with acne inversa. J Clin Invest. 2017 Apr 03;127(4):1485-1490. [PMC free article] [PubMed]19.
Bukvić Mokos Z, Miše J, Balić A, Marinović B. Understanding the Relationship Between Smoking and Hidradenitis Suppurativa. Acta Dermatovenerol Croat. 2020 Jul;28(1):9-13. [PubMed]20.
Vossen ARJV, van Straalen KR, Swolfs EFH, van den Bosch JF, Ardon CB, van der Zee HH. Nicotine Dependency and Readiness to Quit Smoking among Patients with Hidradenitis Suppurativa. Dermatology. 2021;237(3):383-385. [PubMed]21.
Nowak-Liduk A, Kitala D, Ochała-Gierek G, Łabuś W, Bergler-Czop B, Pietrauszka K, Niemiec P, Szyluk K, Gierek M. Hidradenitis Suppurativa: An Interdisciplinary Problem in Dermatology, Gynecology, and Surgery-Pathogenesis, Comorbidities, and Current Treatments. Life (Basel). 2023 Sep 11;13(9) [PMC free article] [PubMed]22.
Chu CB, Yang CC, Tsai SJ. Hidradenitis suppurativa: Disease pathophysiology and sex hormones. Chin J Physiol. 2021 Nov-Dec;64(6):257-265. [PubMed]23.
Kisule A, Kak V, Alamelumangapuram C, Robinson C. Drug-Induced Hidradenitis Suppurativa: A Case Report. Cureus. 2023 Nov;15(11):e49637. [PMC free article] [PubMed]24.
Jfri A, Nassim D, O’Brien E, Gulliver W, Nikolakis G, Zouboulis CC. Prevalence of Hidradenitis Suppurativa: A Systematic Review and Meta-regression Analysis. JAMA Dermatol. 2021 Aug 01;157(8):924-931. [PMC free article] [PubMed]25.
Sinikumpu SP, Jokelainen J, Huilaja L. Prevalence and Characteristics of Hidradenitis Suppurativa in the Northern Finland Birth Cohort 1986 Study: A Cross-sectional Study of 2,775 Subjects. Acta Derm Venereol. 2024 Jan 10;104:adv14732. [PMC free article] [PubMed]26.
Miller IM, McAndrew RJ, Hamzavi I. Prevalence, Risk Factors, and Comorbidities of Hidradenitis Suppurativa. Dermatol Clin. 2016 Jan;34(1):7-16. [PubMed]27.
Greif C, Gibson RS, Kimball AB, Holcomb ZE, Porter ML. Evaluating minority representation across health care settings in hidradenitis suppurativa and psoriasis. Int J Womens Dermatol. 2024 Mar;10(1):e129. [PMC free article] [PubMed]28.
van Straalen KR, Prens EP, Gudjonsson JE. Insights into hidradenitis suppurativa. J Allergy Clin Immunol. 2022 Apr;149(4):1150-1161. [PubMed]29.
Brandao L, Moura R, Tricarico PM, Gratton R, Genovese G, Moltrasio C, Garcovich S, Boniotto M, Crovella S, Marzano AV. Altered keratinization and vitamin D metabolism may be key pathogenetic pathways in syndromic hidradenitis suppurativa: a novel whole exome sequencing approach. J Dermatol Sci. 2020 Jul;99(1):17-22. [PubMed]30.
Prens E, Deckers I. Pathophysiology of hidradenitis suppurativa: An update. J Am Acad Dermatol. 2015 Nov;73(5 Suppl 1):S8-11. [PubMed]31.
von Laffert M, Stadie V, Wohlrab J, Marsch WC. Hidradenitis suppurativa/acne inversa: bilocated epithelial hyperplasia with very different sequelae. Br J Dermatol. 2011 Feb;164(2):367-71. [PubMed]32.
van der Zee HH, Laman JD, Boer J, Prens EP. Hidradenitis suppurativa: viewpoint on clinical phenotyping, pathogenesis and novel treatments. Exp Dermatol. 2012 Oct;21(10):735-9. [PubMed]