Comparing Treatments for Crohn’s Disease: From Steroids, Biologicals, Surgery to Ayurveda

Estimated Reading Time: 10 Minutes


Introduction

Crohn’s disease is a chronic inflammatory bowel disease (IBD) that affects the lining of the digestive tract. It can lead to severe abdominal pain, diarrhea, fatigue, weight loss, and malnutrition (Baumgart & Sandborn, 2012). The inflammation caused by Crohn’s disease often spreads deep into the layers of affected bowel tissue, leading to debilitating symptoms and complications. Managing Crohn’s disease is challenging due to its unpredictable nature and the fact that it can affect any part of the gastrointestinal tract (Hanauer, 2006).

Various treatment options are available, ranging from conventional medical approaches like steroids, biological therapies, and surgery to holistic practices like Ayurveda. This article explores these treatments, comparing their benefits and limitations to help you make informed decisions about managing Crohn’s disease effectively.

Comparing Treatments for Crohn's Disease

Conventional Treatments for Crohn’s Disease

1. Corticosteroids

Corticosteroids, commonly known as steroids, are often prescribed to reduce inflammation in moderate to severe Crohn’s disease (Munkholm, 1997).

  • How They Work: Steroids suppress the immune system’s inflammatory response, decreasing inflammation in the gastrointestinal tract.
  • Benefits:
    • Rapid Symptom Relief: Effective in quickly reducing symptoms during flare-ups (Rutgeerts et al., 1994).
    • Versatility: Available in oral, intravenous, or rectal forms depending on the affected area.
  • Limitations:
    • Short-Term Use: Not suitable for long-term management due to side effects.
    • Side Effects: Potential for weight gain, osteoporosis, high blood pressure, diabetes, and increased susceptibility to infections (Travis et al., 2006).
    • Symptom Management Only: Do not address the underlying causes and may not prevent future flare-ups.

2. Biological Therapies

Biological therapies are medications derived from living organisms that target specific components of the immune system involved in Crohn’s disease (Sandborn et al., 2007).

  • How They Work: These treatments block specific proteins (like TNF-alpha) or cells that contribute to inflammation.
  • Benefits:
    • Targeted Approach: Can induce and maintain remission in moderate to severe cases (Colombel et al., 2010).
    • Improved Quality of Life: May reduce symptoms and promote healing of the intestinal lining (Lichtenstein et al., 2009).
  • Limitations:
    • High Cost: Expensive and may not be accessible to all patients.
    • Potential Side Effects: Increased risk of infections, allergic reactions, and possible development of antibodies reducing effectiveness (Hanauer et al., 2002).
    • Long-Term Safety: Requires regular monitoring; long-term effects are still being studied (Baumgart & Sandborn, 2012).

3. Surgical Interventions

Surgery may be necessary when medications no longer control symptoms or complications arise (Fichera & Michelassi, 2005).

  • Types of Surgery:
    • Resection: Removal of damaged portions of the digestive tract with reconnection of healthy sections.
    • Strictureplasty: Widening of narrowed areas without removing sections.
    • Colectomy: Removal of the entire colon in severe cases (Fichera & Michelassi, 2005).
  • Benefits:
    • Symptom Relief: Can alleviate complications like strictures, fistulas, and bleeding (Rutgeerts et al., 1994).
    • Improved Function: May enhance quality of life when medications fail.
  • Limitations:
    • Not a Cure: Disease may recur in other areas after surgery.
    • Risks of Surgery: Includes infection, complications from anesthesia, and need for additional surgeries (Hanauer, 2006).
    • Lifestyle Impact: Possible need for ostomy bag, dietary changes, and adjustments to daily activities.

Ayurvedic Approach to Crohn’s Disease

Ayurveda, the ancient holistic healing system from India, offers an alternative perspective on managing Crohn’s disease by focusing on restoring balance within the body (Patwardhan et al., 2005).

Understanding Crohn’s Disease in Ayurveda

  • Holistic View: Crohn’s disease is seen as a manifestation of imbalances in the body’s energies or doshas—primarily Vata (air and space) and Pitta (fire) (Gupta & Ramesh, 2017).
  • Digestive Fire (Agni): An imbalance affects the digestive fire, leading to improper digestion and accumulation of toxins (Ama) (Sharma et al., 2020).
  • Focus on Balance: Ayurveda aims to restore harmony among the doshas, addressing the root cause rather than just the symptoms.

Maintaining Long-Term Remission

The primary goal of Ayurvedic treatment for Crohn’s disease is to achieve long-term remission by addressing underlying imbalances and making sustainable lifestyle changes (Patwardhan et al., 2005).

Our approach consists of several phases:

1. Identifying the Root Cause

  • Comprehensive Assessment: Evaluating factors such as diet, lifestyle, stress levels, and other health conditions contributing to the disease (Vasudevan et al., 2011).
  • Understanding Triggers: Identifying specific elements that lead to flare-ups, allowing for personalized interventions.

2. Stabilizing the Body’s Response

  • Balancing Doshas: Implementing dietary and lifestyle modifications to balance Vata and Pitta energies (Patwardhan et al., 2005).
  • Enhancing Digestion: Strengthening the digestive fire (Agni) to improve nutrient absorption and reduce toxin accumulation (Gupta & Ramesh, 2017).
  • Reducing Inflammation: Using natural methods to decrease inflammation and support intestinal healing (Sharma et al., 2020).
  • Enhancing Immunity: Strengthening the body’s natural defenses through herbal formulations and holistic practices (Vasudevan et al., 2011).

3. Preventing Future Flare-Ups

  • Lifestyle Adjustments: Encouraging routines that promote balance, such as regular meal times, adequate sleep, stress management techniques, and appropriate physical activity (Gupta & Ramesh, 2017).
  • Dietary Guidelines: Personalized diet plans focusing on easily digestible foods that pacify aggravated doshas.
  • Ongoing Support: Providing education and tools to empower individuals in managing their condition.
  • Preventive Care: Regular monitoring and adjustments to the treatment plan to maintain remission (Sharma et al., 2020).

The Ayurvedic Perspective on Long-Term Healing

  • Holistic Health: Ayurveda emphasizes the interconnectedness of the body, mind, and spirit. Healing involves restoring balance across all aspects of health (Patwardhan et al., 2005).
  • Sustainable Wellness: Aims for a prolonged state of stability where symptoms are minimal, and overall quality of life is significantly improved (Sharma et al., 2020).
  • Empowerment through Knowledge: By understanding their unique constitution and the factors contributing to Crohn’s disease, individuals can take proactive steps toward wellness (Vasudevan et al., 2011).

Benefits of the Ayurvedic Approach

  • Addresses Root Causes: Focuses on underlying imbalances, aiming to prevent recurrence (Patwardhan et al., 2005).
  • Natural and Gentle: Utilizes natural methods with minimal side effects.
  • Personalized Care: Treatments are tailored to the individual’s specific needs (Gupta & Ramesh, 2017).
  • Improved Quality of Life: Holistic practices can enhance overall well-being beyond just symptom relief (Sharma et al., 2020).

Conclusion: Choosing a Path to Lasting Remission

Crohn’s disease is a complex condition that requires more than just symptom management. While conventional treatments like steroids, biological therapies, and surgery offer necessary relief, they often focus on immediate symptoms without addressing the underlying causes. The Ayurvedic approach provides a holistic alternative that aims for long-term remission by restoring balance within the body and empowering individuals with the knowledge to manage their condition proactively (Patwardhan et al., 2005).

By focusing on identifying root causes, stabilizing the body’s response, and preventing future flare-ups through sustainable lifestyle changes, Ayurveda offers a path toward lasting remission and improved quality of life (Sharma et al., 2020).


Medically reviewed by Dr. Adil Moulanchikkal, Lead Ayurveda Specialist at EliteAyurveda Clinics, with over 15 years of experience in treating neurological, skin, and autoimmune diseases.


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Note: This article is for informational purposes only and is not a substitute for professional medical advice.

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References

  • 1. Actis GC, Pellicano R, Fagoonee S, Ribaldone DG. History of Inflammatory Bowel Diseases. J Clin Med. 2019;8(11):1970. doi: 10.3390/jcm8111970 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  • 2. Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390(10114):2769–2778. doi: 10.1016/S0140-6736(17)32448-0 [PubMed] [CrossRef] [Google Scholar]
  • 3. Farmer RG, Whelan G, Fazio VW. Long-term follow-up of patients with Crohn’s disease. Relationship between the clinical pattern and prognosis. Gastroenterology. 1985;88(6):1818–1825. doi: 10.1016/0016-5085(85)90006-X [PubMed] [CrossRef] [Google Scholar]
  • 4. Solberg IC, Vatn MH, Hoie O, et al. Clinical course in Crohn’s disease: results of a Norwegian population-based ten-year follow-up study. Clin Gastroenterol Hepatol. 2007;5(12):1430–1438. doi: 10.1016/j.cgh.2007.09.002 [PubMed] [CrossRef] [Google Scholar]
  • 5. Thia KT, Sandborn WJ, Harmsen WS, Zinsmeister AR, Loftus EV Jr. Risk factors associated with progression to intestinal complications of Crohn’s disease in a population-based cohort. Gastroenterology. 2010;139(4):1147–1155. doi: 10.1053/j.gastro.2010.06.070 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  • 6. Frolkis AD, Dykeman J, Negron ME, et al. Risk of surgery for inflammatory bowel diseases has decreased over time: a systematic review and meta-analysis of population-based studies. Gastroenterology. 2013;145(5):996–1006. doi: 10.1053/j.gastro.2013.07.041 [PubMed] [CrossRef] [Google Scholar]
  • 7. Bewtra M, Kaiser LM, TenHave T, Lewis JD. Crohn’s disease and ulcerative colitis are associated with elevated standardized mortality ratios: a meta-analysis. Inflamm Bowel Dis. 2013;19(3):599–613. doi: 10.1097/MIB.0b013e31827f27ae [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  • 8. Ekbom A, Helmick C, Zack M, Adami HO. Increased risk of large-bowel cancer in Crohn’s disease with colonic involvement. Lancet. 1990;336(8711):357–359. doi: 10.1016/0140-6736(90)91889-I [PubMed] [CrossRef] [Google Scholar]
  • 9. Friedman S, Rubin PH, Bodian C, Goldstein E, Harpaz N, Present DH. Screening and surveillance colonoscopy in chronic Crohn’s colitis. Gastroenterology. 2001;120(4):820–826. doi: 10.1053/gast.2001.22449 [PubMed] [CrossRef] [Google Scholar]
  • 10. Maykel JA, Hagerman G, Mellgren AF, et al. Crohn’s colitis: the incidence of dysplasia and adenocarcinoma in surgical patients. Dis Colon Rectum. 2006;49(7):950–957. doi: 10.1007/s10350-006-0555-9 [PubMed] [CrossRef] [Google Scholar]
  • 11. Le Berre C, Ananthakrishnan AN, Danese S, Singh S, Peyrin-Biroulet L. Ulcerative colitis and crohn’s disease have similar burden and goals for treatment. Clin Gastroenterol Hepatol. 2020;18(1):14–23. doi: 10.1016/j.cgh.2019.07.005 [PubMed] [CrossRef] [Google Scholar]
  • 12. van der Have M, van der Aalst KS, Kaptein AA, et al. Determinants of health-related quality of life in Crohn’s disease: a systematic review and meta-analysis. J Crohns Colitis. 2014;8(2):93–106. doi: 10.1016/j.crohns.2013.04.007 [PubMed] [CrossRef] [Google Scholar]
  • 13. Floyd DN, Langham S, Severac HC, Levesque BG. The economic and quality-of-life burden of Crohn’s disease in Europe and the United States, 2000 to 2013: a systematic review. Dig Dis Sci. 2015;60(2):299–312. doi: 10.1007/s10620-014-3368-z [PubMed] [CrossRef] [Google Scholar]
  • 14. Gao N, Qiao Z, Yan S, Zhu L. Evaluation of health-related quality of life and influencing factors in patients with Crohn disease. J Int Med Res. 2022;50(5):3000605221098868. doi: 10.1177/03000605221098868 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  • 15. Lundquist LR, Rasmussen B, Waldorff FB, Wehberg S, Kjeldsen J, Haastrup P. Predictors of health-related quality of life in patients with Crohn’s disease receiving biological therapy. Scand J Gastroenterol. 2021;56(12):1434–1441. doi: 10.1080/00365521.2021.1974086 [PubMed] [CrossRef] [Google Scholar]
  • 16. Peyrin-Biroulet L, Panes J, Sandborn WJ, et al. Defining disease severity in inflammatory bowel diseases: current and future directions. Clin Gastroenterol Hepatol. 2016;14(3):348–354 e17. doi: 10.1016/j.cgh.2015.06.001 [PubMed] [CrossRef] [Google Scholar]
  • 17. Koliani-Pace JL, Siegel CA. Beyond disease activity to overall disease severity in inflammatory bowel disease. Lancet Gastroenterol Hepatol. 2017;2(9):624–626. doi: 10.1016/S2468-1253(17)30212-1 [PubMed] [CrossRef] [Google Scholar]
  • 18. Harvey RF, Bradshaw JM. A simple index of Crohn’s-disease activity. Lancet. 1980;1(8167):514. doi: 10.1016/s0140-6736(80)92767-1 [PubMed] [CrossRef] [Google Scholar]
  • 19. Vermeire S, Schreiber S, Sandborn WJ, Dubois C, Rutgeerts P. Correlation between the Crohn’s disease activity and Harvey-Bradshaw indices in assessing Crohn’s disease severity. Clin Gastroenterol Hepatol. 2010;8(4):357–363. doi: 10.1016/j.cgh.2010.01.001 [PubMed] [CrossRef] [Google Scholar]