Autoantibodies against desmoglein 1 and 3, BP180 and BP230 dissolve the anchors holding skin together. What drives them, and the limit of what we claim.
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Gut barrier and mucosal immunity in pemphigus and pemphigoid: what is established, what is only a hypothesis, and why repair must precede any detox.
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Inflammatory load does not create the autoantibody, but it changes the threshold at which disease flares. Sleep, glycaemic control and the steroid burden.
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Gliptins, thiol drugs, checkpoint inhibitors and infections can trigger pemphigus and pemphigoid. Tell your prescriber, and never stop a drug yourself.
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Stress does not cause pemphigus. What it does affect is sleep, glycaemic control, healing and flares, plus pregnancy-related pemphigoid and thyroid overlap.
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